Reactome | Phosphorylation of SMAD2,3 by Activin:Activin Receptor

Phosphorylation of SMAD2,3 by Activin:Activin Receptor

Stable Identifier

R-HSA-1549526

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphorylation of SMAD2,3 by Activin:Activin Receptor

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Activin receptors containing the type II receptors ACVR2A/B (ActRIIA, ActRIIB) and the type I receptors ACVR1B/C (ALK4, ALK7) signal through SMAD2 and SMAD3. The phosphorylated type I receptor (ACVR1B/C) phosphorylates SMAD2 or SMAD3. Homodimers or heterodimers of SMAD2 and SMAD3 bind the co-Smad SMAD4 and the ternary complex (SMAD2/3:SMAD2/3:SMAD4) enters the nucleus and activates expression of target genes.

Literature References

PubMed ID	Title	Journal	Year
16140969	Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells Woodruff, TK, Lee, EJ, Jeruss, JS, Burdette, JE, Kurley, SJ	Cancer Res	2005
17906079	MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4 Wang, Q, Xue, H, Huang, Z, Ju, XL, Jin, C, Han, JD, Chen, YG	Blood	2008
18951876	Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells Yamada, Y, Tsuda, K, Watanabe, R, Shen, ZP	Biochem. Biophys. Res. Commun.	2008
15087470	Receptor internalization-independent activation of Smad2 in activin signaling Klibanski, A, Zhou, Y, Funderburk, SF, Ficociello, LF, Zhang, X, Scolavino, S	Mol Endocrinol	2004
18166170	Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression Childs, AJ, McNeilly, AS, Anderson, RA, Fulton, N, Coutts, SM, Bayne, RA, Collins, C	Dev Biol	2008