Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)

Stable Identifier
R-HSA-1562626
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Ferritin oxidises Fe(2+) ions to Fe(3+), migrates them to its centre, and collects thousands of them as ferric hydroxide (Fe(3+)O(OH)) in the central mineral core from which they can be later remobilised (Harrison & Arrosio 1996).
Literature References
PubMed ID Title Journal Year
8695634 The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, PM, Arosio, P

Biochim Biophys Acta 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ferroxidase activity of Ferritin Complex [cytosol]

Physical Entity
Ferritin Complex [cytosol] (Homo sapiens)
Activity
ferroxidase activity (GO:0004322)
Orthologous Events
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)
Authored
Stephan, R  (2011-01-10)
Reviewed
D'Eustachio, P  (2011-10-26)
Created
Jassal, B  (2011-09-05)
Cite Us!