Reactome | SUCLG2 [mitochondrial matrix]

SUCLG2 [mitochondrial matrix]

Stable Identifier

R-HSA-156628

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Succinyl-CoA synthetase, betaG chain

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96I99 SUCLG2

Gene Names

SUCLG2

Chain

transit peptide:1-37, chain:38-432

Reference Genes

BioGPS Gene:8801 SUCLG2

COSMIC (genes):SUCLG2 SUCLG2

CTD Gene:8801 SUCLG2

dbSNP Gene:8801 SUCLG2

ENSEMBL:ENSG00000172340 SUCLG2

ENSEMBL_homo_sapiens_GENE:ENSG00000172340.15 SUCLG2

HGNC:11450 SUCLG2

KEGG Gene (Homo sapiens):8801 SUCLG2

Monarch:8801 SUCLG2

NCBI Gene:8801 SUCLG2

OMIM:603922 SUCLG2

UCSC:Q96I99 SUCLG2

Reference Transcript

Other Identifiers

11717610_s_at

11756967_x_at

16955975

212459_PM_x_at

212459_x_at

214835_PM_s_at

214835_s_at

215772_PM_x_at

215772_x_at

2680814

2680820

2680821

2680833

2680858

2680860

2680862

2680867

2680868

2680869

2680870

2680891

2680892

2680903

3426659

3426661

3426663

3426665

39252_at

8088664

8801

A_21_P0000093

A_23_P99249

A_33_P3636590

GE62884

GO:0000166

GO:0000287

GO:0003824

GO:0004776

GO:0005515

GO:0005524

GO:0005525

GO:0005737

GO:0005739

GO:0005759

GO:0005886

GO:0006091

GO:0006099

GO:0006104

GO:0006105

GO:0006790

GO:0016874

GO:0019003

GO:0032991

GO:0042709

GO:0043226

GO:0044877

GO:0045244

GO:0046872

GO:0055086

GO:1901135

GO:1901289

HMNXSV003036163

HMNXSV003037377

Hs.247309.0.A1_3p_a_at

Hs.247309.0.A1_3p_x_at

Hs.247309.1.S1_3p_a_at

ILMN_1652379

PH_hs_0031681

TC03001533.hg

Participates

as a member of

Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)

as a component of

SUCLG2:Mg2+ [mitochondrial matrix] (Homo sapiens)

Inferred To

SUCLG2 [mitochondrial matrix] (Bos taurus)

SUCLG2 [mitochondrial matrix] (Caenorhabditis elegans)

SUCLG2 [mitochondrial matrix] (Canis familiaris)

SUCLG2 [mitochondrial matrix] (Dictyostelium discoideum)

SUCLG2 [mitochondrial matrix] (Drosophila melanogaster)

SUCLG2 [mitochondrial matrix] (Gallus gallus)

SUCLG2 [mitochondrial matrix] (Mus musculus)

SUCLG2 [mitochondrial matrix] (Plasmodium falciparum)

SUCLG2 [mitochondrial matrix] (Rattus norvegicus)

SUCLG2 [mitochondrial matrix] (Sus scrofa)

SUCLG2 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_003839.2, NP_001171070.1

OpenTargets

ENSG00000172340

GeneCards

Q96I99

HPA

ENSG00000172340-SUCLG2

Ensembl

ENSP00000307432, ENSP00000419325, ENST00000307227, ENSG00000172340, ENST00000493112

PRO

Q96I99

Pharos - Targets

Q96I99

Orphanet

24957

HMDB Protein

HMDBP00891

PDB

7MSS, 7MST, 6WCV, 7MSR

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.656	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5

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