Reactome | RBM8A [nucleoplasm]

RBM8A [nucleoplasm]

Stable Identifier

R-HSA-156659

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RBM8A/Y14

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
  - mRNA 3'-end processing (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
    - mRNA polyadenylation (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        RBM8A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5S9 RBM8A

Gene Names

RBM8A, RBM8, HSPC114, MDS014

Chain

initiator methionine:, chain:2-174

Reference Genes

BioGPS Gene:9939 RBM8A

COSMIC (genes):RBM8A RBM8A

CTD Gene:9939 RBM8A

dbSNP Gene:9939 RBM8A

ENSEMBL:ENSG00000265241 RBM8A

ENSEMBL_homo_sapiens_GENE:ENSG00000265241.8 RBM8A

HGNC:9905 RBM8A

KEGG Gene (Homo sapiens):9939 RBM8A

Monarch:9939 RBM8A

NCBI Gene:9939 RBM8A

OMIM:605313 RBM8A

UCSC:Q9Y5S9 RBM8A

Reference Transcript

RefSeq:NM_005105.4 RBM8A

Other Identifiers

11717422_s_at

11717423_s_at

11758777_x_at

11763501_s_at

16669830

16669840

213852_PM_at

213852_at

214113_3p_s_at

214113_PM_s_at

214113_s_at

217856_PM_at

217856_at

217857_PM_s_at

217857_s_at

222443_PM_s_at

222443_s_at

2355705

2356182

2356183

2356188

2356191

2356193

2356195

2356197

2356198

2356199

2356200

2356201

2356202

2356203

2356204

2356206

2356207

2356208

2356209

2356210

3538612

3538613

3538614

3538615

3538616

3538617

3538618

40819_at

40820_at

64886_at

7904751

8180286

9939

A_14_P139097

A_23_P104116

A_24_P79955

A_32_P62571

GE58355

GE61533

GO:0000184

GO:0000381

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006396

GO:0006397

GO:0006406

GO:0006417

GO:0006913

GO:0008380

GO:0016071

GO:0016607

GO:0030425

GO:0035145

GO:0043025

GO:0043226

GO:0050684

GO:0051028

GO:0071006

GO:0071013

GO:1990501

GO:2000622

HMNXSV003033005

Hs.65648.0.S3_3p_at

Hs.65648.1.A1_3p_s_at

Hs.65648.2.A1_3p_at

ILMN_1781870

PH_hs_0030984

TC01001093.hg

g10197629_3p_s_at

g4826971_3p_s_at

Participates

as a component of

Magoh-Y14 complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RBM8A [cytosol]

Inferred To

RBM8A [nucleoplasm] (Canis familiaris)

RBM8A [nucleoplasm] (Gallus gallus)

RBM8A [nucleoplasm] (Plasmodium falciparum)

RBM8A [nucleoplasm] (Schizosaccharomyces pombe)

RBM8A [nucleoplasm] (Sus scrofa)

rbm8a [nucleoplasm] (Danio rerio)

rbm8a [nucleoplasm] (Xenopus tropicalis)

rnp-4 [nucleoplasm] (Caenorhabditis elegans)

tsu [nucleoplasm] (Drosophila melanogaster)

rbm8A [nucleoplasm] (Dictyostelium discoideum)

Rbm8a [nucleoplasm] (Mus musculus)

Rbm8a [nucleoplasm] (Rattus norvegicus)

Ghost homologue of RBM8A [nucleoplasm] (Bos taurus)

Ghost homologue of RBM8A [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_005096.1

OpenTargets

ENSG00000265241

HPA

ENSG00000265241-RBM8A

GeneCards

Q9Y5S9

Ensembl

ENSG00000265241, ENSP00000488265, ENSP00000510519, ENST00000632555, ENSP00000358313, ENST00000583313, ENST00000691760, ENSP00000463058, ENST00000369307

PRO

Q9Y5S9

Pharos - Targets

Q9Y5S9

Orphanet

21071

PDB

5XJC, 7W59, 7A5P, 7ZNJ, 3EX7, 2XB2, 7W5A, 8C6J, 2HYI, 2J0S, 7W5B, 5YZG, 1P27, 2J0Q, 6ICZ, 6QDV

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.947	22
UniProt:Q9BZI7 UPF3B	2	UPF3B [nucleoplasm] (R-HSA-156776) UPF3B [cytosol] (R-HSA-159258)	0.914	10
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.857	6
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.725	5
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.643	3
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.564	2
UniProt:Q13838 DDX39B	2	DDX39B [cytosol] (R-HSA-9715154) DDX39B [nucleoplasm] (R-HSA-8849139)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.527	2
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.512	3

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