Reactome | Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS

Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS

Stable Identifier

R-HSA-1566981

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS

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MMP1 can degrade fibronectin (Fukai et al. 1995), as can MMP3 (Gunja-Smith et al. 1985, Nicholson et al. 1989, Wilhelm et al. 1993, Fukai et al. 1995), MMP7 (Quantin et al. 1989, Miyazaki et al. 1990, Fukai et al. 1995, von Bredow et al. 1995), MMP10 (Nicholson et al. 1989), MMP12 (Gronski et al. 1997), MMP13 (Knauper et al. 1997), MMP14 (Shi & Sottile 2011) and 19 (Stracke et al. 2000). Cathepsin S is able to degrade fibronectin (Taleb et al. 2006). Studies have shown that fibronectin turnover is not prevented by protease inhibitors (Sottile & Hocking 2002) suggesting that caveolin-1-mediated endocytosis and intracellular degradation are involved (Salicioni et al. 2002, Sottile & Chandler 2004).

Literature References

PubMed ID	Title	Journal	Year
7547873	Release of biological activities from quiescent fibronectin by a conformational change and limited proteolysis by matrix metalloproteinases Fukai, F, Yajima, H, Ohtaki, M, Miyazaki, K, Ishii, T, Katayama, T, Nishizawa, Y, Fujii, N	Biochemistry	1995
10809722	Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme Murphy, G, Knäuper, V, López-Otin, C, Stracke, JO, Hutton, M, Stewart, M, Pendás, AM, Smith, B	J. Biol. Chem.	2000
16825321	Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation Taleb, S, Clément, K, Cancello, R, Lacasa, D	Endocrinology	2006
9115292	Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase Kobayashi, DK, Gronski TJ, Jr, Martin, RL, Van Wart, HE, Holman, MC, Huber, M, Walsh, BC, Shapiro, SD	J Biol Chem	1997
9065415	The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction O'Shea, M, Cowell, S, Morris, H, Smith, B, Zardi, L, López-Otin, C, Knäuper, V, Murphy, G	J Biol Chem	1997