Reactome | Inactivation of Wee1 kinase

Inactivation of Wee1 kinase

Stable Identifier

R-HSA-156699

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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*Plk1 is shown to phosphorylate Wee1A, an event that is likely critical for recognition and ubiquitination of Wee1A by SCF and therefore for the subsequent degradation of Wee1A . **Plk1 phosphorylates Wee1A at S53, creating the second phosphodegron, PD53. ** Evidence also exists in budding yeast that the budding yeast polo homolog Cdc5 directly phosphorylates and down-regulate the budding yeast Wee1 ortholog Swe1. Thus, polo kinase-dependent phosphorylation and degradation of Wee1A (or Swe1) is likely conserved throughout evolution and is critical for normal mitotic entry.

Literature References

PubMed ID	Title	Journal	Year
15070733	M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP Nishihara, Y, Taniguchi, M, Arai, H, Watanabe, N, Osada, H, Hunter, T, Watanabe, N	Proc Natl Acad Sci U S A	2004
15037762	Coupling morphogenesis to mitotic entry Park, JE, Lee, KS, Veenstra, TD, Cho, YW, Sakchaisri, K, Yu, LR, Asano, S, Park, CJ, Shulewitz, MJ, Thorner, J	Proc Natl Acad Sci U S A	2004