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activated thrombin (factor IIa) [extracellular region]
Stable Identifier
R-HSA-156786
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FIIa
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
Defective factor VIII causes hemophilia A (Homo sapiens)
Defective F8 cleavage by thrombin (Homo sapiens)
F8 variant is not cleaved by thrombin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Defective factor XII causes hereditary angioedema (Homo sapiens)
Cleavage of factor XII variant by activated thrombin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
factor V -> factor Va + factor V activation peptide (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Thrombin binding to GP1b:IX:V (Homo sapiens)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Thrombin, ELANE cleave C5 (Homo sapiens)
Activated thrombin, (ELANE) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Proteinase-activated receptors can bind thrombin (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Participants
components
x 6
Ca2+ [extracellular region]
thrombin heavy chain [extracellular region]
(Homo sapiens)
thrombin light chain [extracellular region]
(Homo sapiens)
Participates
as a component of
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
as an input of
Thrombin binding to GP1b:IX:V (Homo sapiens)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)
Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)
Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)
Proteinase-activated receptors can bind thrombin (Homo sapiens)
as an output of
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)
as a member of
Activated thrombin, (ELANE) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Inferred To
activated thrombin (factor IIa) [extracellular region]
(Bos taurus)
activated thrombin (factor IIa) [extracellular region]
(Canis familiaris)
activated thrombin (factor IIa) [extracellular region]
(Gallus gallus)
activated thrombin (factor IIa) [extracellular region]
(Mus musculus)
activated thrombin (factor IIa) [extracellular region]
(Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region]
(Sus scrofa)
activated thrombin (factor IIa) [extracellular region]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-6222
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