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PABPC1 [cytosol]
Stable Identifier
R-HSA-156803
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PABP
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9UL18 AGO1
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1 binds translation and heat shock proteins (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11940 PABPC1
Gene Names
PABPC1, PAB1, PABP, PABP1, PABPC2
Chain
chain:1-636
Reference Genes
BioGPS Gene:26986 PABPC1
COSMIC (genes):PABPC1 PABPC1
CTD Gene:26986 PABPC1
dbSNP Gene:26986 PABPC1
ENSEMBL:ENSG00000070756 PABPC1
HGNC:8554 PABPC1
KEGG Gene (Homo sapiens):26986 PABPC1
Monarch:26986 PABPC1
NCBI Gene:26986 PABPC1
OMIM:604679 PABPC1
UCSC:P11940 PABPC1
Reference Transcript
RefSeq:NM_002568.3 PABPC1
RefSeq:XM_005250861.2 PABPC1
Other Identifiers
0002510739
11748097_x_at
11752278_x_at
11754246_x_at
17079672
215157_3p_x_at
215157_PM_x_at
215157_x_at
26986
2701791
2766680
3146787
3146788
3146789
3146791
3146793
3146794
3146795
3146796
3146799
3146801
3146802
3146805
3146806
3146807
3146809
3146812
3146814
3146815
3146819
3146820
3146821
3146822
3146823
3146824
3146825
3146826
3146827
31950_at
31951_s_at
3419625
3419626
3482124
59809_f_at
64962_r_at
8152079
GE60230
GO:0000184
GO:0000398
GO:0003674
GO:0003676
GO:0003723
GO:0003729
GO:0003730
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005681
GO:0005737
GO:0005829
GO:0005925
GO:0006378
GO:0006397
GO:0006412
GO:0008022
GO:0008143
GO:0008150
GO:0008266
GO:0008380
GO:0008494
GO:0009056
GO:0009058
GO:0010494
GO:0016020
GO:0030027
GO:0031047
GO:0031252
GO:0032991
GO:0034641
GO:0034655
GO:0036464
GO:0042995
GO:0043226
GO:0045070
GO:0048255
GO:0060213
GO:0070062
GO:0070934
GO:0071013
GO:0106002
GO:1900152
GO:1900153
GO:1990904
GO:2000623
GO:2000767
HMNXSV003038156
Hs.172182.2.A1_3p_s_at
ILMN_2136133
PH_hs_0028309
TC08001481.hg
U68105_s_at
Z48501_s_at
Participates
as a component of
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
as an input of
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
AUF1 binds translation and heat shock proteins (Homo sapiens)
as an output of
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
Inferred To
Dmel\CG4612 [cytosol]
(Drosophila melanogaster)
Homologues of PABPC1 [cytosol]
(Caenorhabditis elegans)
Homologues of PABPC1 [cytosol]
(Dictyostelium discoideum)
Homologues of PABPC1 [cytosol]
(Drosophila melanogaster)
Homologues of PABPC1 [cytosol]
(Plasmodium falciparum)
Homologues of PABPC1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PABPC1 [cytosol]
(Schizosaccharomyces pombe)
pabpc1B [cytosol]
(Dictyostelium discoideum)
rnp24 [cytosol]
(Schizosaccharomyces pombe)
PAB1 [cytosol]
(Saccharomyces cerevisiae)
pabpc1A [cytosol]
(Dictyostelium discoideum)
pab-2 [cytosol]
(Caenorhabditis elegans)
crp79 [cytosol]
(Schizosaccharomyces pombe)
pAbp [cytosol]
(Drosophila melanogaster)
pabpc1a [cytosol]
(Danio rerio)
pab-1 [cytosol]
(Caenorhabditis elegans)
pabpc1 [cytosol]
(Xenopus tropicalis)
PES4 [cytosol]
(Saccharomyces cerevisiae)
pab1 [cytosol]
(Schizosaccharomyces pombe)
PABPC1 [cytosol]
(Bos taurus)
PABPC1 [cytosol]
(Canis familiaris)
PABPC1 [cytosol]
(Dictyostelium discoideum)
PABPC1 [cytosol]
(Gallus gallus)
PABPC1 [cytosol]
(Plasmodium falciparum)
PABPC1 [cytosol]
(Sus scrofa)
MIP6 [cytosol]
(Saccharomyces cerevisiae)
Pabpc1 [cytosol]
(Mus musculus)
Pabpc1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_002559.2
,
XP_005250918.1
OpenTargets
ENSG00000070756
GeneCards
P11940
HPA
ENSG00000070756-PABPC1
Ensembl
ENSP00000429790
,
ENSP00000429892
,
ENSP00000429119
,
ENST00000521865
,
ENST00000318607
,
ENSP00000428749
,
ENSP00000313007
,
ENST00000522658
,
ENSP00000428840
,
ENST00000520804
,
ENSP00000430012
,
ENST00000523555
,
ENSG00000070756
,
ENST00000522720
,
ENST00000520142
PRO
P11940
Pharos - Targets
P11940
PDB
2X04
,
2RQH
,
3PTH
,
2RQG
,
5DXA
,
3KUJ
,
5DX8
,
3KUS
,
1CVJ
,
3KTP
,
5LGS
,
3KUR
,
4F02
,
1JH4
,
3PKN
,
5DX1
,
3KTR
,
5LGR
,
1G9L
,
1JGN
,
3KUT
,
3KUI
,
4F26
,
4F25
,
2K8G
,
5LGP
,
5LGQ
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H074 PAIP1
1
PAIP1 [cytosol]
(R-HSA-429861)
0.966
20
UniProt:Q9HCJ0 TNRC6C
1
TNRC6C [cytosol]
(R-HSA-427776)
0.941
22
UniProt:Q8IYD1 GSPT2
1
GSPT2 [cytosol]
(R-HSA-143379)
0.855
8
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.835
6
UniProt:Q99700 ATX2
0.826
7
UniProt:Q9BPZ3 PAIP2
0.804
6
UniProt:O00571 DDX3X
3
DDX3X [secretory granule lumen]
(R-HSA-6801275)
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
0.789
10
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.725
4
UniProt:Q58A45 PAN3
1
PAN3 [cytosol]
(R-HSA-429938)
0.704
4
UniProt:P50616 TOB1
0.683
5
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.662
9
UniProt:Q14106 TOB2
0.656
6
UniProt:Q9UPQ9 TNRC6B
1
TNRC6B [cytosol]
(R-HSA-427777)
0.656
3
UniProt:Q9UKV8 AGO2
2
EIF2C2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.643
6
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.589
2
UniProt:Q8NDV7 TNRC6A
2
TNRC6A [cytosol]
(R-HSA-427769)
TNRC6A [nucleoplasm]
(R-HSA-5578976)
0.564
3
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.558
5
UniProt:Q99700-5 Q997005
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O43432 EIF4G3
1
EIF4G3 [cytosol]
(R-HSA-1678827)
0.544
2
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.527
2
UniProt:P33469 NCAP
0.527
2
UniProt:Q9UL18 AGO1
2
EIF2C1 [nucleoplasm]
(R-HSA-5578686)
EIF2C1 [cytosol]
(R-HSA-210616)
0.527
4
UniProt:O95503 CBX6
1
CBX6 [nucleoplasm]
(R-HSA-3229071)
0.527
2
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.527
3
UniProt:P67809 YBX1
3
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
2
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.527
2
UniProt:Q15366 PCBP2
2
PCBP2 [nucleoplasm]
(R-HSA-71921)
PCBP2 [cytosol]
(R-HSA-983457)
0.527
2
UniProt:Q96Q15 SMG1
1
SMG1 [cytosol]
(R-HSA-927760)
0.499
2
UniProt:Q9J0X9 Q9J0X9
0.499
3
UniProt:P35568 IRS1
5
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
IRS1 [cytosol]
(R-HSA-74769)
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
0.499
2
UniProt:Q86U42 PABPN1
1
PABPN1 [nucleoplasm]
(R-HSA-72008)
0.499
2
UniProt:P0C6U8-PRO_0000338257
0.499
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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