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Peptide transfer from P-site tRNA to the A-site tRNA
Stable Identifier
R-HSA-156912
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The A- and P-sites of the ribosome positions the aa-tRNA and peptidyl-tRNA such that a nucleophilic attack can occur between the amine group of the A-site aa-tRNA and the carbonyl group of the growing peptide chain on the P-site tRNA, resulting in the formation of a peptide bond. The carboxyl end of the peptide chain is uncoupled from the tRNA molecule in the P-site and forms a new peptide bond with the amino acid that is in the A-site.
This process is illustrated below with: a peptidyl-tRNA with a growing peptide,a deacylated tRNA with an -OH and a ribosome with A,P and E sites to accommodate these three forms of tRNA.
Participants
Input
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol]
(Homo sapiens)
Output
Elongation complex with growing peptide chain [cytosol]
(Homo sapiens)
Participates
as an event of
Peptide chain elongation (Homo sapiens)
Catalyst Activity
peptidyltransferase activity of 80S ribosome [cytosol]
Physical Entity
80S ribosome [cytosol]
(Homo sapiens)
Activity
peptidyltransferase activity (GO:0000048)
Inferred From
Peptide transfer from P-site tRNA to the A-site tRNA (Escherichia coli)
Created
Kinzy, TG (2005-03-17)
Balar, B (2005-03-17)
Ulloque, R (2005-03-17)
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