Reactome | EEF1D [cytosol]

EEF1D [cytosol]

Stable Identifier

R-HSA-156914

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

EF-1-delta , Elongation factor 1-delta, eEF1B delta

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P29692 EEF1D

Gene Names

EEF1D, EF1D

Chain

initiator methionine:, chain:2-281

Reference Genes

BioGPS Gene:1936 EEF1D

COSMIC (genes):EEF1D EEF1D

CTD Gene:1936 EEF1D

dbSNP Gene:1936 EEF1D

ENSEMBL:ENSG00000104529 EEF1D

HGNC:3211 EEF1D

KEGG:hsa:1936 EEF1D

Monarch:1936 EEF1D

NCBI Gene:1936 EEF1D

OMIM:130592 EEF1D

UCSC:P29692 EEF1D

Reference Transcript

Participates

as an input of

Formation of eEF1B complex (Homo sapiens)

as a component of

eEF1B complex [cytosol] (Homo sapiens)

Inferred To

EFB1 [cytosol] (Saccharomyces cerevisiae)

tef5 [cytosol] (Schizosaccharomyces pombe)

EEF1D [cytosol] (Bos taurus)

EEF1D [cytosol] (Canis familiaris)

EEF1D [cytosol] (Gallus gallus)

EEF1D [cytosol] (Plasmodium falciparum)

EEF1D [cytosol] (Sus scrofa)

Eef1d [cytosol] (Mus musculus)

Eef1d [cytosol] (Rattus norvegicus)

Homologues of EEF1D [cytosol] (Plasmodium falciparum)

efa1B [cytosol] (Dictyostelium discoideum)

eEF1delta [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000104529

ENSEMBL

ENST00000442189, ENST00000530445, ENST00000531218, ENST00000529516, ENST00000632587, ENST00000618139, ENST00000614575, ENSP00000487680, ENST00000528610, ENSP00000436542, ENSP00000435697, ENSP00000478340, ENSP00000378551, ENST00000419152, ENST00000615067, ENSP00000433412, ENST00000619144, ENST00000534377, ENST00000620155, ENSP00000480505, ENSP00000317399, ENSP00000488026, ENST00000615698, ENST00000632675, ENSP00000488672, ENST00000524624, ENSP00000483527, ENSP00000436933, ENSP00000434872, ENSP00000431460, ENSP00000484536, ENSP00000477608, ENSP00000431742, ENST00000533494, ENST00000631698, ENSP00000431763, ENST00000526838, ENSP00000391944, ENSG00000273594, ENSP00000388261, ENST00000534380, ENSP00000436507, ENSP00000433611, ENSG00000104529, ENSP00000479653, ENST00000632965, ENSP00000434448, ENSP00000488275, ENST00000395119, ENST00000530191, ENST00000317198, ENST00000529272

GeneCards

EEF1D

HPA

ENSG00000104529-EEF1D

PRO

P29692

Pharos - Targets

P29692

GlyGen

P29692

HMDB Protein

HMDBP08368

PDB

2N51, 5JPO, 2MVM, 2MVN

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.813	8
UniProt:Q96DN0 ERP27			0.743	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.742	6
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.666	4
UniProt:P00441 SOD1	5	SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [extracellular region] (R-HSA-350705)	0.564	3
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.564	5
UniProt:P26641-2 EEF1G			0.556	3
UniProt:P13693 TCTP			0.556	3
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.553	2
UniProt:Q969K4 ABTB1			0.547	3
UniProt:P55197 AF10			0.527	2
UniProt:P35453 HXD13			0.527	3
UniProt:Q08AD1 CAMP2			0.524	2
UniProt:O95352 ATG7	14	ATG7 [cytosol] (R-HSA-947867) CysO572-ATG7 [cytosol] (R-HSA-5683584) CysO572-ATG7-GARABAPL3 [cytosol] (R-HSA-9820420) CysO572-ATG7-MAP1LC3A [cytosol] (R-HSA-9820421) CysO572-ATG7-MAP1LC3C [cytosol] (R-HSA-9820407) CysO572-ATG7-GARABAPL1 [cytosol] (R-HSA-9820406) CysO572-ATG7-GARABAP [cytosol] (R-HSA-9820417) CysO572-ATG7-GARABAPL2 [cytosol] (R-HSA-9820413) CysO572-ATG7-MAP1LC3B [cytosol] (R-HSA-9820410) ATG7(1-693)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802517) ATG7(1-693)-BRAF(381-766) fusion [cytosol] (R-HSA-6802272) ATG7 [ficolin-1-rich granule lumen] (R-HSA-6801293) ATG7 [extracellular region] (R-HSA-6806451) ATG7 [secretory granule lumen] (R-HSA-6801316)	0.524	2
UniProt:Q5T5U3 ARHGAP21	1	ARHGAP21 [cytosol] (R-HSA-8873918)	0.524	2
UniProt:Q67020 Q67020			0.508	2
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	4