Reactome | EEF1B2 [cytosol]

EEF1B2 [cytosol]

Stable Identifier

R-HSA-156926

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

EF-1-beta, Elongation factor 1-beta, eEF1B beta

Locations in the PathwayBrowser for interactor UniProt:P26641 EEF1G

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External Reference Information

External Reference

UniProt:P24534 EEF1B2

Gene Names

EEF1B2, EEF1B, EF1B

Chain

initiator methionine:, chain:2-225

Reference Genes

BioGPS Gene:1933 EEF1B2

COSMIC (genes):EEF1B2 EEF1B2

CTD Gene:1933 EEF1B2

dbSNP Gene:1933 EEF1B2

ENSEMBL:ENSG00000114942 EEF1B2

ENSEMBL_homo_sapiens_GENE:ENSG00000114942.15 EEF1B2

ENSEMBL_homo_sapiens_GENE:ENSG00000283391.3 EEF1B2

HGNC:3208 EEF1B2

KEGG Gene (Homo sapiens):1933 EEF1B2

Monarch:1933 EEF1B2

NCBI Gene:1933 EEF1B2

OMIM:600655 EEF1B2

UCSC:P24534 EEF1B2

Reference Transcript

Other Identifiers

11720183_s_at

11720184_x_at

16889938

1933

200705_PM_s_at

200705_s_at

2524579

2524580

2524581

2524582

2524584

2524585

2524586

2524590

2524595

2524599

2524600

2524601

2860353

3073096

3073097

3073098

3073102

3073104

35748_at

3594257

4003081

4003083

4003085

4003087

8047771

A_23_P165535

GE79016

GO:0003746

GO:0005085

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0005853

GO:0006412

GO:0006414

GO:0043226

GO:0045182

GO:0098772

HMNXSV003015623

ILMN_1675541

ILMN_1685678

ILMN_1694587

ILMN_1701930

ILMN_2318725

PH_hs_0019741

PH_hs_0039722

TC02001212.hg

X60489_at

g4503476_3p_s_at

Participates

as an input of

Formation of eEF1B complex (Homo sapiens)

as a component of

eEF1B complex [cytosol] (Homo sapiens)

Inferred To

eEF1beta [cytosol] (Drosophila melanogaster)

EEF1B [cytosol] (Bos taurus)

Eef1b [cytosol] (Mus musculus)

EFB1 [cytosol] (Saccharomyces cerevisiae)

EEF1B2 [cytosol] (Canis familiaris)

EEF1B2 [cytosol] (Gallus gallus)

EEF1B2 [cytosol] (Plasmodium falciparum)

EEF1B2 [cytosol] (Sus scrofa)

tef5 [cytosol] (Schizosaccharomyces pombe)

Eef1b2 [cytosol] (Rattus norvegicus)

eef-1B.1 [cytosol] (Caenorhabditis elegans)

efa1B [cytosol] (Dictyostelium discoideum)

eef1b [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001032752.1, NP_001950.1, NP_066944.1

OpenTargets

ENSG00000114942

GeneCards

P24534

HPA

ENSG00000114942-EEF1B2

Ensembl

ENSP00000376056, ENSG00000283391, ENST00000392222, ENSP00000489993, ENSP00000236957, ENSG00000114942, ENSP00000490326, ENST00000236957, ENST00000636275, ENST00000635728

PRO

P24534

Pharos - Targets

P24534

HMDB Protein

HMDBP08367

PDB

1B64, 5DQS

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.885	12
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.669	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q8WW59 SPRY4			0.556	3
UniProt:P26641-2 EEF1G			0.556	3
UniProt:P55198 AF17			0.527	3
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.527	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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