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NOTCH1 [plasma membrane]
Stable Identifier
R-HSA-157027
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NTM-NEC 1 heterodimer
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Processing in Golgi (Homo sapiens)
Mature NOTCH heterodimer traffics to the plasma membrane (Homo sapiens)
NOTCH [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
ARRB mediates NOTCH1 ubiquitination (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Ub-NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)
Ub-DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
DLL4:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
JAG1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
DTX binds NOTCH1 (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:NUMB:ITCH [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 binds DLK1 (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:DLK1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:DLL/JAG [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 binds DLL1 (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 binds DLL4 (Homo sapiens)
DLL4:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 binds DNER (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 binds JAG1 (Homo sapiens)
JAG1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 binds JAG2 (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
DLL4:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
JAG1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Ub-DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL/JAG:NOTCH1 [plasma membrane] (Homo sapiens)
DLL1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
DLL4:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
JAG1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)
NOTCH1:NUMB:ITCH [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Ub-NOTCH1:NUMB:ITCH [plasma membrane] (Homo sapiens)
Ub-NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1 [plasma membrane] (Homo sapiens)
Participants
components
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region]
(Homo sapiens)
NOTCH1(1665-2555) [plasma membrane]
(Homo sapiens)
Participates
as a component of
Ub-NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:NUMB:ITCH [plasma membrane] (Homo sapiens)
NOTCH1:DLK1 [plasma membrane] (Homo sapiens)
rDll1:NOTCH1 [plasma membrane] (Homo sapiens)
NOTCH1:DLL/JAG [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
JAG2:NOTCH1 [plasma membrane] (Homo sapiens)
JAG1:NOTCH1 [plasma membrane] (Homo sapiens)
as an input of
NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)
NOTCH1 binds DLK1 (Homo sapiens)
rDll1 binds NOTCH1 in cis (Homo sapiens)
NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)
DTX binds NOTCH1 (Homo sapiens)
NOTCH1 binds JAG1 (Homo sapiens)
NOTCH1 binds JAG2 (Homo sapiens)
as a member of
NOTCH [plasma membrane] (Homo sapiens)
NOTCH1/Fringe-modified NOTCH1 [plasma membrane] (Homo sapiens)
Inferred To
NOTCH1 [plasma membrane]
(Gallus gallus)
NOTCH1 [plasma membrane]
(Mus musculus)
NOTCH1 [plasma membrane]
(Xenopus tropicalis)
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