Reactome | ADAM10 [plasma membrane]

ADAM10 [plasma membrane]

Stable Identifier

R-HSA-157237

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ADAM 10 metalloprotease, KUZ

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O14672 ADAM10

Gene Names

ADAM10, KUZ, MADM

Chain

signal peptide:1-19, propeptide:20-213, chain:214-748

Reference Genes

BioGPS Gene:102 ADAM10

COSMIC (genes):ADAM10 ADAM10

CTD Gene:102 ADAM10

dbSNP Gene:102 ADAM10

ENSEMBL:ENSG00000137845 ADAM10

ENSEMBL_homo_sapiens_GENE:ENSG00000137845.15 ADAM10

HGNC:188 ADAM10

KEGG Gene (Homo sapiens):102 ADAM10

Monarch:102 ADAM10

NCBI Gene:102 ADAM10

OMIM:602192 ADAM10

UCSC:O14672 ADAM10

Reference Transcript

RefSeq:NM_001110.3 ADAM10

Other Identifiers

102

11736026_at

11736027_a_at

11736028_x_at

11751180_a_at

16809880

202603_PM_at

202603_at

202604_PM_x_at

202604_x_at

214895_PM_s_at

214895_s_at

3626560

3626561

3626562

3626563

3626564

3626565

3626566

3626567

3626568

3626569

3626570

3626571

3626572

3626574

3626579

3626580

3626582

3626584

3626585

3626588

3626589

3626590

3626592

3626593

3626595

3626596

3626607

3626608

3626614

3626615

3626635

3626648

3626649

3626650

3626653

3626654

3626655

40797_at

40798_s_at

58036_at

68865_r_at

7989224

A_23_P48886

A_33_P3243857

GE54099

GE60416

GE773164

GO:0000139

GO:0001701

GO:0002376

GO:0003824

GO:0004175

GO:0004222

GO:0005102

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005798

GO:0005886

GO:0005912

GO:0005925

GO:0006468

GO:0006508

GO:0006509

GO:0007155

GO:0007162

GO:0007219

GO:0007229

GO:0007267

GO:0008233

GO:0008237

GO:0008284

GO:0008593

GO:0009986

GO:0010629

GO:0010820

GO:0014069

GO:0016020

GO:0016485

GO:0016787

GO:0017124

GO:0019538

GO:0019901

GO:0022617

GO:0023052

GO:0030136

GO:0030163

GO:0030198

GO:0030307

GO:0030335

GO:0030424

GO:0030425

GO:0031410

GO:0034330

GO:0034332

GO:0034612

GO:0035579

GO:0036211

GO:0038004

GO:0042117

GO:0042803

GO:0042987

GO:0042995

GO:0043226

GO:0043231

GO:0046872

GO:0046930

GO:0046931

GO:0048856

GO:0048870

GO:0051089

GO:0051128

GO:0051604

GO:0060090

GO:0065003

GO:0070062

GO:0070161

GO:0070573

GO:0070821

GO:0090102

GO:0097038

GO:0097060

GO:0097197

GO:0098696

GO:0098978

GO:0099173

GO:0099175

GO:0140096

GO:0140249

GO:0140448

GO:1901342

GO:1901998

GO:1902945

HMNXSV003010919

Hs.172028.0.A2_3p_at

ILMN_1718946

ILMN_2148360

PH_hs_0010303

TC15001484.hg

Z48579_at

g4557250_3p_a_at

Participates

as a member of

as an output of

ADAM10 cleaves EFNAs (Homo sapiens)

as a component of

Other forms of this molecule

ADAM10(215-824) [plasma membrane]

ADAM10 [endoplasmic reticulum lumen]

p-ADAM10 [endoplasmic reticulum lumen]

ADAM10 [tertiary granule membrane]

ADAM10 [specific granule membrane]

Inferred To

ADAM10 [plasma membrane] (Bos taurus)

ADAM10 [plasma membrane] (Caenorhabditis elegans)

ADAM10 [plasma membrane] (Canis familiaris)

ADAM10 [plasma membrane] (Drosophila melanogaster)

ADAM10 [plasma membrane] (Gallus gallus)

ADAM10 [plasma membrane] (Mus musculus)

ADAM10 [plasma membrane] (Rattus norvegicus)

ADAM10 [plasma membrane] (Sus scrofa)

ADAM10 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001101.1

Guide to Pharmacology - Targets

1658

OpenTargets

ENSG00000137845

ZINC - Substances

ADA10_HUMAN

ZINC target

O14672

PRO

O14672

PDB

6BDZ, 6BE6, 8ESV

HPA

ENSG00000137845-ADAM10

GeneCards

O14672

Ensembl

ENST00000260408, ENSG00000137845, ENSP00000260408

Pharos - Targets

O14672

ZINC - Predictions - Purchasable

ADA10_HUMAN

Orphanet

22244

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95858 TSPAN15	2	TSPAN15 [plasma membrane] (R-HSA-9010043) TSPAN15 [endoplasmic reticulum lumen] (R-HSA-9010117)	0.799	11
UniProt:P62079 TSPAN5	2	TSPAN5 [plasma membrane] (R-HSA-9010031) TSPAN5 [endoplasmic reticulum lumen] (R-HSA-9010081)	0.799	12
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.752	17
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.744	9
UniProt:Q8NG11 TSPAN14	4	TSPAN14 [endoplasmic reticulum lumen] (R-HSA-9010066) TSPAN14 [specific granule membrane] (R-HSA-6799708) TSPAN14 [plasma membrane] (R-HSA-6800467) TSPAN14 [tertiary granule membrane] (R-HSA-6800899)	0.742	9
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.659	7
UniProt:Q86UF1 TSPAN33	2	TSPAN33 [plasma membrane] (R-HSA-9010024) TSPAN33 [endoplasmic reticulum lumen] (R-HSA-9010054)	0.621	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.602	5
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.602	3
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.544	2
UniProt:Q96RF0 SNX18	1	SNX18 [cytosol] (R-HSA-8868038)	0.544	2
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.544	3
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.544	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.544	3
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.544	3
UniProt:Q9P2B2 FPRP			0.527	4
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.527	6
UniProt:O95859 TSN12			0.499	2
UniProt:P56817 BACE1	8	BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.454	3

Cite Us!