Reactome | PSENEN [plasma membrane]

PSENEN [plasma membrane]

Stable Identifier

R-HSA-157331

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PEN-2

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        gamma-secretase cleaves EPHB2 (Homo sapiens)
        
        gamma-secretase complex [plasma membrane] (Homo sapiens)
        
        PSENEN [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZ42 PSENEN

Gene Names

PSENEN, PEN2, MDS033

Chain

chain:1-101

Reference Genes

BioGPS Gene:55851 PSENEN

COSMIC (genes):PSENEN PSENEN

CTD Gene:55851 PSENEN

dbSNP Gene:55851 PSENEN

ENSEMBL:ENSG00000205155 PSENEN

ENSEMBL_homo_sapiens_GENE:ENSG00000205155.8 PSENEN

HGNC:30100 PSENEN

KEGG Gene (Homo sapiens):55851 PSENEN

Monarch:55851 PSENEN

NCBI Gene:55851 PSENEN

OMIM:607632 PSENEN

UCSC:Q9NZ42 PSENEN

Reference Transcript

Other Identifiers

11719381_a_at

16861193

218302_PM_at

218302_at

3830790

3830791

3830792

3830793

3830794

3830796

3830797

3830798

3830799

3830800

3830801

3830802

46950_at

55851

64441_at

8027996

8028002

A_24_P48587

GE61732

GO:0000139

GO:0005515

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006509

GO:0007219

GO:0007220

GO:0010008

GO:0010950

GO:0016020

GO:0016485

GO:0019899

GO:0023052

GO:0031293

GO:0031410

GO:0032580

GO:0034205

GO:0042734

GO:0042982

GO:0042987

GO:0043085

GO:0043226

GO:0051604

GO:0061133

GO:0070765

GO:0098772

HMNXSV003035958

ILMN_1669718

PH_hs_0014645

PH_hs_0032484

TC19002630.hg

g8923937_3p_at

g8923937_3p_x_at

Participates

as a component of

gamma-secretase complex [plasma membrane] (Homo sapiens)

Other forms of this molecule

PSENEN [endosome membrane]

Inferred To

pen-2 [plasma membrane] (Caenorhabditis elegans)

pen-2 [plasma membrane] (Drosophila melanogaster)

PSENEN [plasma membrane] (Bos taurus)

PSENEN [plasma membrane] (Canis familiaris)

PSENEN [plasma membrane] (Sus scrofa)

Psenen [plasma membrane] (Mus musculus)

Psenen [plasma membrane] (Rattus norvegicus)

psenen [plasma membrane] (Danio rerio)

psenen [plasma membrane] (Xenopus tropicalis)

Ghost homologue of PSENEN [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_001268461.1, NP_758844.1

OpenTargets

ENSG00000205155

ZINC - Substances

PEN2_HUMAN

HPA

ENSG00000205155-PSENEN

GeneCards

Q9NZ42

ZINC target

Q9NZ42

Ensembl

ENSG00000205155, ENST00000587708, ENSP00000468411, ENSP00000222266, ENST00000222266

PRO

Q9NZ42

Pharos - Targets

Q9NZ42

Orphanet

20182

ZINC - Predictions - Purchasable

PEN2_HUMAN

PDB

6IDF, 5FN2, 7C9I, 6LQG, 7D8X, 7Y5X, 5FN3, 8OQZ, 5FN5, 8K8E, 5A63, 7Y5T, 6IYC, 7Y5Z, 6LR4, 5FN4, 8OQY, 8IM7

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q12908 SLC10A2	1	SLC10A2 [plasma membrane] (R-HSA-194173)	0.556	3