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NICD4 [cytosol]
Stable Identifier
R-HSA-157636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NOTCH4(1467-2003), NICD 4 fragment, N4ICD
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves NOTCH4 (Homo sapiens)
NICD4 [cytosol] (Homo sapiens)
NICD4 traffics to the nucleus (Homo sapiens)
NICD4 [cytosol] (Homo sapiens)
NOTCH4 Intracellular Domain Regulates Transcription (Homo sapiens)
NOTCH4 binds SMAD3 (Homo sapiens)
NICD4 [cytosol] (Homo sapiens)
NICD4:p-S423,S425-SMAD3 [cytosol] (Homo sapiens)
NICD4 [cytosol] (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
AKT1 phosphorylates NOTCH4 (Homo sapiens)
NICD4 [cytosol] (Homo sapiens)
NICD4 binds to TACC3 (Homo sapiens)
NICD4 [cytosol] (Homo sapiens)
NICD4:TACC3 [cytosol] (Homo sapiens)
NICD4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99466 NOTCH4
Gene Names
NOTCH4, INT3
Chain
signal peptide:1-23, chain:24-2003, chain:1432-2003, chain:1467-2003
Reference Genes
BioGPS Gene:4855 NOTCH4
COSMIC (genes):NOTCH4 NOTCH4
CTD Gene:4855 NOTCH4
dbSNP Gene:4855 NOTCH4
ENSEMBL:ENSG00000204301 NOTCH4
HGNC:7884 NOTCH4
KEGG:hsa:4855 NOTCH4
Monarch:4855 NOTCH4
NCBI Gene:4855 NOTCH4
OMIM:164951 NOTCH4
UCSC:Q99466 NOTCH4
Reference Transcript
RefSeq:NM_004557.3 NOTCH4
Other Identifiers
11721965_a_at
11746752_a_at
11748539_a_at
11751705_a_at
17017814
17027038
17029639
17034630
17037128
17039839
17042335
205247_PM_at
205247_at
240786_PM_at
240786_at
2949899
2949900
2949902
2949903
2949904
2949905
2949906
2949907
2949908
2949909
2949911
2949912
2949913
2949914
2949915
2949916
2949917
2949918
2949919
2949920
2949921
2949922
2949923
2949924
2949925
2949926
2949927
2949928
2949929
2949931
2949932
2949933
2949934
2949935
2949936
2949937
2949939
2949940
2949941
2949942
2949943
2949944
2949945
2949946
2949947
2949949
2949950
2949952
2949954
2949955
2949956
2949957
2949958
2949959
2949960
2949962
39048_at
4855
57139_at
8125383
A_23_P365614
A_24_P26496
GE59595
GO:0000122
GO:0000139
GO:0000987
GO:0001228
GO:0001569
GO:0001709
GO:0001763
GO:0001837
GO:0001944
GO:0003677
GO:0005112
GO:0005509
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006355
GO:0007219
GO:0007221
GO:0007275
GO:0009986
GO:0016020
GO:0030097
GO:0030154
GO:0030879
GO:0038023
GO:0042060
GO:0043226
GO:0045596
GO:0045602
GO:0045893
GO:0045944
GO:0046872
GO:0048589
GO:0048856
GO:0050793
GO:0051152
GO:0060089
GO:0060354
GO:0140110
GO:2000048
HMNXSV003054488
Hs.11689.0.S2_3p_at
Hs.224880.0.A1_3p_at
ILMN_1711157
PH_hs_0025474
TC06001564.hg
TC6_apd_hap1000098.hg
TC6_cox_hap2000190.hg
TC6_mann_hap4000155.hg
TC6_mcf_hap5000165.hg
TC6_qbl_hap6000179.hg
TC6_ssto_hap7000159.hg
U89335_cds2_at
Participates
as a component of
NICD4:p-S423,S425-SMAD3 [cytosol] (Homo sapiens)
NICD4:TACC3 [cytosol] (Homo sapiens)
as an input of
NOTCH4 binds SMAD3 (Homo sapiens)
NICD4 binds to TACC3 (Homo sapiens)
AKT1 phosphorylates NOTCH4 (Homo sapiens)
NICD4 traffics to the nucleus (Homo sapiens)
as an output of
Gamma-secretase cleaves NOTCH4 (Homo sapiens)
Other forms of this molecule
NOTCH4(1432-1466) [plasma membrane]
NEXT4 [plasma membrane]
p-4S-NICD4 [cytosol]
p-NICD4 [nucleoplasm]
PolyUb-p-NICD4 [nucleoplasm]
NOTCH4(1337-2003) [Golgi membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) [Golgi membrane]
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region]
NOTCH4(1337-2003) [plasma membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [Golgi membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]
12xFucT-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]
Pre-NOTCH4 [endoplasmic reticulum membrane]
FRINGE-modified NOTCH4 Extracellular fragment (NECD4) [Golgi membrane]
FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) [plasma membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
Glc,GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
NICD4 [nucleoplasm]
Inferred To
Homologues of NICD4 [cytosol]
(Caenorhabditis elegans)
Homologues of NICD4 [cytosol]
(Drosophila melanogaster)
lin-12 [cytosol]
(Caenorhabditis elegans)
crb [cytosol]
(Drosophila melanogaster)
NICD4 [cytosol]
(Bos taurus)
NICD4 [cytosol]
(Caenorhabditis elegans)
NICD4 [cytosol]
(Gallus gallus)
NICD4 [cytosol]
(Rattus norvegicus)
NICD4 [cytosol]
(Sus scrofa)
C901 [cytosol]
(Drosophila melanogaster)
Ser [cytosol]
(Drosophila melanogaster)
Notch4 [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_004548.3
Guide to Pharmacology - Targets
2862
OpenTargets
ENSG00000204301
ENSEMBL
ENST00000457094
,
ENST00000425600
,
ENST00000375023
,
ENST00000439349
,
ENSP00000403447
,
ENSP00000408335
,
ENSP00000401321
,
ENSP00000364163
HPA
ENSG00000204301-NOTCH4
ZINC - Substances
NOTC4_HUMAN
ZINC target
Q99466
PRO
Q99466
Pharos - Targets
Q99466
ZINC - Predictions - Purchasable
NOTC4_HUMAN
PDB
7OR7
,
7OR3
,
7OR5
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
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