Reactome | NEXT2 is cleaved to produce NICD2

NEXT2 is cleaved to produce NICD2

Stable Identifier

R-HSA-157640

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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NEXT2 fragment of NOTCH2 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD2 into the cytosol (Saxena et al. 2001, De Strooper et al. 1999, Schroeter et al. 1998, Fortini 2002).

Literature References

PubMed ID	Title	Journal	Year
24842903	Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins Groot, AJ, Habets, R, Vooijs, M, Saftig, P, Hodin, CM, Theys, J, Reiss, K, Yahyanejad, S	Mol. Cell. Biol.	2014
11518718	Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis Saxena, MT, Kopan, R, Schroeter, EH, Mumm, JS	J Biol Chem	2001
12209127	Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling Fortini, ME	Nat Rev Mol Cell Biol	2002
9620803	Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Kopan, R, Kisslinger, JA, Schroeter, EH	Nature	1998
10206645	A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain Wolfe, MS, Kopan, R, De Strooper, B, Schrijvers, V, Schroeter, EH, Cupers, P, Goate, A, Saftig, P, Craessaerts, K, Ray, WJ, Mumm, JS, Annaert, W	Nature	1999