Reactome | KLKB1(20-390) [plasma membrane]

KLKB1(20-390) [plasma membrane]

Stable Identifier

R-HSA-158213

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

KLKB1, kallikrein heavy chain

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P03952 KLKB1

Gene Names

KLKB1, KLK3

Chain

signal peptide:1-19, chain:20-390, chain:391-638

Reference Genes

BioGPS Gene:3818 KLKB1

COSMIC (genes):KLKB1 KLKB1

CTD Gene:3818 KLKB1

dbSNP Gene:3818 KLKB1

ENSEMBL:ENSG00000164344 KLKB1

ENSEMBL:ENSG00000164344.17 KLKB1

HGNC:6371 KLKB1

KEGG Gene (Homo sapiens):3818 KLKB1

Monarch:3818 KLKB1

NCBI Gene:3818 KLKB1

OMIM:229000 KLKB1

UCSC:P03952 KLKB1

Reference Transcript

RefSeq:NM_000892.4 KLKB1

Other Identifiers

11727252_a_at

16973061

206541_PM_at

206541_at

2755120

2755123

2755124

2755125

2755127

2755129

2755130

2755134

2755135

2755138

2755139

2755141

2755144

2755145

2755146

2755147

2755149

2755150

2755151

2755152

2755153

32353_at

3818

8098654

A_14_P139132

A_23_P252236

GE57815

GO:0002542

GO:0003824

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006508

GO:0006954

GO:0007596

GO:0007599

GO:0008233

GO:0008236

GO:0016787

GO:0031638

GO:0031639

GO:0042060

GO:0042730

GO:0043226

GO:0051604

GO:0051919

GO:0070062

GO:0140096

HMNXSV003015729

ILMN_1800468

M13143_at

PH_hs_0000253

TC04002915.hg

g9257226_3p_at

Participates

as a component of

kallikrein [plasma membrane] (Homo sapiens)

Other forms of this molecule

KLKB1(20-390) [extracellular region]

KLKB1(391-638) [extracellular region]

KLKB1(20-638) [plasma membrane]

KLKB1(391-638) [plasma membrane]

Inferred To

KLKB1 [plasma membrane] (Bos taurus)

KLKB1 [plasma membrane] (Sus scrofa)

Klkb1 [plasma membrane] (Mus musculus)

Klkb1 [plasma membrane] (Rattus norvegicus)

Homologues of KLKB1(20-390) [plasma membrane] (Danio rerio)

klkb1 [plasma membrane] (Xenopus tropicalis)

KLKB1(20-390) [plasma membrane] (Danio rerio)

KLKB1(20-390) [plasma membrane] (Gallus gallus)

wu:fk84e06 [plasma membrane] (Danio rerio)

zmp:0000001114 [plasma membrane] (Danio rerio)

st14 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_000883.2

Guide to Pharmacology - Targets

2379

OpenTargets

ENSG00000164344

ZINC - Substances

KLKB1_HUMAN

ZINC target

P03952

PRO

P03952

PDB

6T7P, 6O1G, 2ANW, 5F8T, 5F8Z, 4OGY, 6I44, 8A3Q, 6O1S, 7N7X, 5F8X, 4OGX, 2ANY, 7QOX, 5TJX

ZINC - Investigational

KLKB1_HUMAN

GeneCards

P03952

HPA

ENSG00000164344-KLKB1

Ensembl

ENSG00000164344, ENSP00000264690, ENST00000264690

Pharos - Targets

P03952

Orphanet

16310

ZINC - Predictions - Purchasable

KLKB1_HUMAN

HMDB Protein

HMDBP02080

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UI10 EIF2B4	1	EIF2B4 [cytosol] (R-HSA-72521)	0.556	3
UniProt:Q9UMY4 SNX12			0.556	3
UniProt:A0A024R9H7 A0A024R9H7			0.556	3
UniProt:O43493-5 O434935			0.556	3
UniProt:O00233 PSMD9	2	PSMD9 [nucleoplasm] (R-HSA-174321) PSMD9 [cytosol] (R-HSA-68810)	0.556	3
UniProt:C9J082 C9J082			0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.556	3
UniProt:Q8NFB2 T185A			0.556	3
UniProt:Q8TAS3 Q8TAS3			0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3