Reactome | Bradykinin [extracellular region]

Bradykinin [extracellular region]

Stable Identifier

R-HSA-158344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

KNG1(381-389)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01042 KNG1

Gene Names

KNG1, BDK, KNG

Chain

signal peptide:1-18, chain:19-644, chain:19-380, peptide:376-389, peptide:380-389, peptide:381-389, chain:390-644, peptide:431-434

Reference Genes

BioGPS Gene:3827 KNG1

COSMIC (genes):KNG1 KNG1

CTD Gene:3827 KNG1

dbSNP Gene:3827 KNG1

ENSEMBL:ENSG00000113889 KNG1

ENSEMBL_homo_sapiens_GENE:ENSG00000113889.14 KNG1

HGNC:6383 KNG1

KEGG Gene (Homo sapiens):3827 KNG1

Monarch:3827 KNG1

NCBI Gene:3827 KNG1

OMIM:612358 KNG1

UCSC:P01042 KNG1

Reference Transcript

Other Identifiers

11729956_a_at

11729957_x_at

11739129_at

11750241_x_at

16949348

206054_PM_at

206054_at

217512_PM_at

217512_at

243562_PM_at

243562_at

2656690

2656691

2656692

2656693

2656694

2656697

2656699

2656700

2656701

2656702

2656703

2656704

2656705

2656707

2656708

2656709

2656710

2656711

2656712

2656713

2656714

2656731

37234_at

37235_g_at

37236_at

3827

56482_at

8084679

89933_at

A_23_P212258

A_24_P60381

A_32_P230808

GE517374

GE60500

GO:0003013

GO:0004869

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005886

GO:0006954

GO:0007155

GO:0007162

GO:0007165

GO:0007204

GO:0007596

GO:0007599

GO:0008201

GO:0008270

GO:0012501

GO:0023052

GO:0030195

GO:0030312

GO:0030414

GO:0031012

GO:0031093

GO:0031410

GO:0042060

GO:0042311

GO:0043065

GO:0043226

GO:0045861

GO:0048018

GO:0062023

GO:0070062

GO:0072562

GO:0097746

GO:0098772

HMNXSV003004823

HMNXSV003008016

Hs.117112.0.A1_3p_at

Hs.289056.0.S1_3p_at

ILMN_1753729

M11437_cds1_at

M11437_cds2_at

PH_hs_0004485

TC03001024.hg

g4504892_3p_at

Participates

as an output of

kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)

as a member of

Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)

as an input of

Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)

as a component of

Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)

Other forms of this molecule

KNG1(19-644) [platelet alpha granule lumen]

KNG1(19-380) [plasma membrane]

KNG1(390-644) [plasma membrane]

KNG1(19-644) [plasma membrane]

KNG1(19-644) [extracellular region]

p-KNG1 [endoplasmic reticulum lumen]

KNG1 [endoplasmic reticulum lumen]

Inferred To

KNG1 [extracellular region] (Bos taurus)

KNG1 [extracellular region] (Canis familiaris)

KNG1 [extracellular region] (Sus scrofa)

kng1 [extracellular region] (Xenopus tropicalis)

Bradykinin [extracellular region] (Gallus gallus)

Kng1 [extracellular region] (Rattus norvegicus)

Kng2 [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_001095886.1, NP_001159923.1, NP_000884.1

OpenTargets

ENSG00000113889

HPA

ENSG00000113889-KNG1

GeneCards

P01042

Ensembl

ENST00000447445, ENST00000644859, ENSP00000493985, ENSP00000396025, ENSP00000287611, ENST00000287611, ENSG00000113889

PRO

P01042

Pharos - Targets

P01042

Orphanet

16311

HMDB Protein

HMDBP02063

PDB

7F2O, 7QOT, 7F6I, 2WOK, 6F3Y, 6F27, 5I25, 7F6H, 6F3X, 7EIB, 4ASR, 4ECC, 1NY2, 7QOX, 4ASQ, 6F3W, 4ECB, 6F3V

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q10714	2	ACE(30-1306) [plasma membrane] (R-DME-508496-2) ACE(30-1232) [extracellular region] (R-DME-2065414-2)	0.558	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.544	4