factor XIIa binds SERPING1

Stable Identifier
R-HSA-158357
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
factor XIIa + C1Inh -> factor XIIa:C1Inh
ReviewStatus
5/5
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factor XIIa binds SERPING1
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Activated factor XII (factor XIIa) binds to C1Inh (C1 inhibitor - Bock et al. 1986) to form a stable, inactive complex (Schneider et al. 1973). While several protease inhibitors can form stable complexes with XIIa in vitro, only C1Inh does so to a significant extent under normal conditions in vivo (Pixley et al. 1985).
Literature References
PubMed ID Title Journal Year
3756141 Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization

Nielsen, E, Marrinan, J, Donaldson, VH, Thogersen, HC, Skriver, K, Eddy, RL, Magnusson, S, Bock, SC, Wiman, B, Huber, R, Radziejewska, E

Biochemistry 1986
2578463 The regulation of human factor XIIa by plasma proteinase inhibitors

Schapira, M, Pixley, RA, Colman, RW

J Biol Chem 1985
4703226 Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation

Kaplan, AP, Austen, KF, Schreiber, AD

J Clin Invest 1973
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of blood coagulation, intrinsic pathway (2000267)
Orthologous Events
factor XIIa binds SERPING1 (Bos taurus)
factor XIIa binds SERPING1 (Mus musculus)
factor XIIa binds SERPING1 (Rattus norvegicus)
factor XIIa binds SERPING1 (Sus scrofa)
Authored
D'Eustachio, P  (2005-01-20)
Created
D'Eustachio, P  (2005-01-20)
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