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DLL4 [plasma membrane]
Stable Identifier
R-HSA-158437
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Delta 4 ligand
Icon
Locations in the PathwayBrowser for interactor UniProt:P57105 SYJ2B
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
NOTCH1 binds DLL4 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
DLL4 binds NOTCH2 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NOTCH3 binds DLL4 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
DLL4 binds NOTCH4 (Homo sapiens)
DLL4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NR61 DLL4
Gene Names
DLL4, UNQ1895/PRO4341
Chain
signal peptide:1-26, chain:27-685
Reference Genes
BioGPS Gene:54567 DLL4
COSMIC (genes):DLL4 DLL4
CTD Gene:54567 DLL4
dbSNP Gene:54567 DLL4
ENSEMBL:ENSG00000128917 DLL4
HGNC:2910 DLL4
KEGG:hsa:54567 DLL4
Monarch:54567 DLL4
NCBI Gene:54567 DLL4
OMIM:605185 DLL4
UCSC:Q9NR61 DLL4
Reference Transcript
RefSeq:NM_019074.3 DLL4
Other Identifiers
11739649_at
11739650_at
16799724
223525_PM_at
223525_at
3590240
3590241
3590242
3590243
3590244
3590245
3590246
3590247
3590248
3590249
3590250
3590254
3590255
3590256
3590257
3590259
3590260
3590261
3590262
52819_at
54567
7982854
A_23_P419641
GE563878
GE61397
GO:0000122
GO:0001525
GO:0001569
GO:0001974
GO:0002376
GO:0003180
GO:0003208
GO:0003209
GO:0003222
GO:0003344
GO:0005112
GO:0005509
GO:0005515
GO:0005886
GO:0006355
GO:0007154
GO:0007165
GO:0007219
GO:0007275
GO:0007399
GO:0007601
GO:0008285
GO:0010596
GO:0010628
GO:0010629
GO:0016020
GO:0030154
GO:0030217
GO:0032502
GO:0035912
GO:0035924
GO:0043537
GO:0044344
GO:0045746
GO:0045747
GO:0048018
GO:0048856
GO:0050767
GO:0050877
GO:0060579
GO:0061074
GO:0072554
GO:0090051
GO:0098772
GO:1903588
GO:2000179
HMNXSV003027258
ILMN_1690174
PH_hs_0026343
TC15000299.hg
g10567109_3p_at
Participates
as a component of
DLL4:NOTCH1 HD domain mutant fragments [extracellular region] (Homo sapiens)
DLL4:NOTCH1 HD domain mutants [plasma membrane] (Homo sapiens)
DLL4:NOTCH1 [plasma membrane] (Homo sapiens)
DLL4:NOTCH3 [plasma membrane] (Homo sapiens)
DLL4:NOTCH4 [plasma membrane] (Homo sapiens)
DLL4:Notch4 [plasma membrane] (Homo sapiens)
DLL4:NOTCH2 [plasma membrane] (Homo sapiens)
DLL4:NOTCH1 PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL4:NOTCH1 HD+PEST Domain Mutants [plasma membrane] (Homo sapiens)
DLL4:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] (Homo sapiens)
as an input of
NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)
NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)
NOTCH3 binds DLL4 (Homo sapiens)
NOTCH1 binds DLL4 (Homo sapiens)
DLL4 binds NOTCH4 (Homo sapiens)
DLL4 binds Notch4 (Homo sapiens)
DLL4 binds NOTCH2 (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)
NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)
as a member of
DLL/JAG [plasma membrane] (Homo sapiens)
as a candidate of
DLL1, (DLL4, JAG1, JAG2) [plasma membrane] (Homo sapiens)
Other forms of this molecule
Ub-DLL4 [plasma membrane]
Inferred To
dll4 [plasma membrane]
(Danio rerio)
DLL4 [plasma membrane]
(Bos taurus)
DLL4 [plasma membrane]
(Canis familiaris)
DLL4 [plasma membrane]
(Gallus gallus)
DLL4 [plasma membrane]
(Sus scrofa)
Delta [plasma membrane]
(Drosophila melanogaster)
Dll4 [plasma membrane]
(Mus musculus)
Dll4 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_061947.1
ENSEMBL
ENST00000249749
,
ENSP00000249749
OpenTargets
ENSG00000128917
HPA
ENSG00000128917-DLL4
PRO
Q9NR61
Pharos - Targets
Q9NR61
GlyGen
Q9NR61
Orphanet
DLL4
PDB
5MVX
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P57105 SYJ2B
0.556
3
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