SULT1A1 dimer sulfonates PARA to PARA-SO4

Stable Identifier
R-HSA-158468
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Acetaminophen can form an O- sulfate conjugate
ReviewStatus
5/5
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Cytosolic sulfotransferase 1A1 (SULT1A1), in dimeric form, can sulfonate the widely used analgesic and antipyretic drug paracetamol (PARA aka acetaminophen). Around 20-30% of PARA is metabolised via sulfonation by the liver (Parkinson 1995, Yamazoe et al. 1995, Strott 2002).
Literature References
PubMed ID Title Journal Year
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
12372849 Sulfonation and molecular action

Strott, CA

Endocr Rev 2002
10503886 Sulfotransferase catalyzing sulfation of heterocyclic amines

Shiraga, T, Iwasaki, K, Fujita, K, Yoshinari, K, Yamazoe, Y, Nagata, K

Cancer Lett 1999
Participants
Participates
Catalyst Activity

aryl sulfotransferase activity of SULT1A1 dimer [cytosol]

Orthologous Events
Reviewed
Created
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