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ALYREF [cytosol]
Stable Identifier
R-HSA-158482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
THOC4(Aly/Ref)
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Mature intronless derived mRNA:TAP:Aly/Ref complex [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Mature intronless derived mRNA:TAP:Aly/Ref complex [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Transport of the SLBP Dependant Mature mRNA (Homo sapiens)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex [cytosol] (Homo sapiens)
ALYREF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86V81 ALYREF
Gene Names
ALYREF, ALY, BEF, THOC4
Chain
initiator methionine:, chain:2-257
Reference Genes
BioGPS Gene:10189 ALYREF
COSMIC (genes):ALYREF ALYREF
CTD Gene:10189 ALYREF
dbSNP Gene:10189 ALYREF
ENSEMBL:ENSG00000183684 ALYREF
HGNC:19071 ALYREF
KEGG Gene (Homo sapiens):10189 ALYREF
Monarch:10189 ALYREF
NCBI Gene:10189 ALYREF
OMIM:604171 ALYREF
Reference Transcript
RefSeq:NM_005782.3 ALYREF
Participates
as an output of
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
as a component of
Mature intronless derived mRNA:TAP:Aly/Ref complex [cytosol] (Homo sapiens)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [cytosol] (Homo sapiens)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
Other forms of this molecule
ALYREF [nucleoplasm]
Inferred To
Ref1 [cytosol]
(Drosophila melanogaster)
aly-3 [cytosol]
(Caenorhabditis elegans)
Alyref [cytosol]
(Mus musculus)
Alyref [cytosol]
(Rattus norvegicus)
ALYREF [cytosol]
(Bos taurus)
ALYREF [cytosol]
(Canis familiaris)
ALYREF [cytosol]
(Gallus gallus)
ALYREF [cytosol]
(Schizosaccharomyces pombe)
ALYREF [cytosol]
(Sus scrofa)
Ghost homologue of ALYREF [cytosol]
(Saccharomyces cerevisiae)
alyref [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005773.3
OpenTargets
ENSG00000183684
GeneCards
Q86V81
PRO
Q86V81
Pharos - Targets
Q86V81
PDB
3ULH
,
7ZNJ
,
7ZNK
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13838 DDX39B
2
DDX39B [cytosol]
(R-HSA-9715154)
DDX39B [nucleoplasm]
(R-HSA-8849139)
0.768
5
UniProt:Q96FV9 THOC1
1
THOC1 [nucleoplasm]
(R-HSA-8849130)
0.749
7
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.656
4
UniProt:Q8NI27 THOC2
1
THOC2 [nucleoplasm]
(R-HSA-8849134)
0.643
4
UniProt:Q53F19 NCBP3
0.643
6
UniProt:Q07021 C1QBP
3
C1QBP [cytosol]
(R-HSA-9645690)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [plasma membrane]
(R-HSA-158123)
0.643
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.639
5
UniProt:Q13769 THOC5
3
THOC5 [nucleoplasm]
(R-HSA-8849111)
THOC5 [cytosol]
(R-HSA-9682751)
p-Y-THOC5 [cytosol]
(R-HSA-9682738)
0.623
5
UniProt:Q2HR75 MTA
0.621
4
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.597
3
UniProt:Q9Y3Y2 CHTOP
1
CHTOP [nucleoplasm]
(R-HSA-8849147)
0.558
8
UniProt:Q99873 PRMT1
2
PRMT1 [cytosol]
(R-HSA-9632173)
PRMT1 [nucleoplasm]
(R-HSA-3215140)
0.527
2
UniProt:Q9H1J1 UPF3A
1
UPF3A [cytosol]
(R-HSA-927801)
0.527
2
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.527
2
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.527
2
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
3
UniProt:Q6I9Y2 THOC7
1
THOC7 [nucleoplasm]
(R-HSA-8849145)
0.527
2
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.499
4
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
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