Reactome | SERPINE1 [extracellular region]

SERPINE1 [extracellular region]

Stable Identifier

R-HSA-158797

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Plasminogen activator inhibitor-1, PAI1

Icon

Locations in the PathwayBrowser for interactor UniProt:P00749 PLAU

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External Reference Information

External Reference

UniProt:P05121 SERPINE1

Gene Names

SERPINE1, PAI1, PLANH1

Chain

signal peptide:1-23, chain:24-402

Reference Genes

BioGPS Gene:5054 SERPINE1

COSMIC (genes):SERPINE1 SERPINE1

CTD Gene:5054 SERPINE1

dbSNP Gene:5054 SERPINE1

ENSEMBL:ENSG00000106366 SERPINE1

ENSEMBL_homo_sapiens_GENE:ENSG00000106366.9 SERPINE1

HGNC:8583 SERPINE1

KEGG Gene (Homo sapiens):5054 SERPINE1

Monarch:5054 SERPINE1

NCBI Gene:5054 SERPINE1

OMIM:173360 SERPINE1

UCSC:P05121 SERPINE1

Reference Transcript

RefSeq:NM_000602.4 SERPINE1

Other Identifiers

11715636_a_at

11746856_a_at

11757312_x_at

17049676

202627_PM_s_at

202627_s_at

202628_PM_s_at

202628_s_at

3016149

3016150

3016153

3016154

3016158

3016161

3016163

3016166

3016168

3016170

3016172

38125_at

5054

672_at

8135069

A_14_P105272

A_14_P119092

A_24_P158089

GE57824

GO:0001525

GO:0002020

GO:0002376

GO:0004867

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006954

GO:0007155

GO:0010469

GO:0010757

GO:0010951

GO:0012501

GO:0014912

GO:0016192

GO:0023052

GO:0030154

GO:0030194

GO:0030195

GO:0030312

GO:0030336

GO:0030414

GO:0031012

GO:0031093

GO:0031410

GO:0032757

GO:0033629

GO:0035491

GO:0042060

GO:0042730

GO:0043226

GO:0045766

GO:0048260

GO:0048856

GO:0048870

GO:0050729

GO:0050829

GO:0051604

GO:0051918

GO:0061044

GO:0061045

GO:0062023

GO:0070062

GO:0071222

GO:0090026

GO:0090399

GO:0097180

GO:0097187

GO:0098542

GO:0098772

GO:1901331

GO:1902042

GO:1904090

GO:2000098

GO:2000352

HMNXSV003055269

Hs.82085.0.S1_3p_a_at

ILMN_1744381

J03764_at

PH_hs_0024995

TC07000643.hg

TC07002499.hg

X04729_s_at

g10835158_3p_a_at

Participates

as an input of

as a component of

as a member of

as an output of

Other forms of this molecule

SERPINE1 [plasma membrane]

SERPINE1 [platelet alpha granule lumen]

Inferred To

Serpine1 [extracellular region] (Mus musculus)

Serpine1 [extracellular region] (Rattus norvegicus)

Spn28Dc [extracellular region] (Drosophila melanogaster)

Spn77Ba [extracellular region] (Drosophila melanogaster)

Spn77Bc [extracellular region] (Drosophila melanogaster)

Spn77Bb [extracellular region] (Drosophila melanogaster)

serpine1 [extracellular region] (Danio rerio)

serpine1 [extracellular region] (Xenopus tropicalis)

Homologues of SERPINE1 [extracellular region] (Drosophila melanogaster)

Homologues of SERPINE1 [extracellular region] (Sus scrofa)

SERPINE1 [extracellular region] (Bos taurus)

SERPINE1 [extracellular region] (Canis familiaris)

SERPINE1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000593.1

OpenTargets

ENSG00000106366

ZINC - Substances

PAI1_HUMAN

ZINC target

P05121

ZINC - Biogenic

PAI1_HUMAN

PRO

P05121

PDB

7AQF, 3CVM, 4G8R, 6GWN, 1A7C, 7AQG, 6GWP, 4IC0, 1DVN, 3Q03, 3EOX, 1LJ5, 4G8O, 6GWQ, 1DVM, 3Q02, 4AQH, 6I8S, 5ZLZ, 6ZRV, 1DB2, 9PAI, 3UT3, 1OC0, 1C5G, 3PB1, 1B3K, 5BRR, 3R4L

ZINC - Investigational

PAI1_HUMAN

HPA

ENSG00000106366-SERPINE1

GeneCards

P05121

Ensembl

ENSG00000106366, ENST00000223095, ENSP00000223095

Pharos - Targets

P05121

Orphanet

15273

ZINC - Predictions - Purchasable

PAI1_HUMAN

HMDB Protein

HMDBP01864

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.718	6
UniProt:Q96EQ0 SGTB			0.718	6
UniProt:P00749 PLAU	6	PLAU(21-177) [plasma membrane] (R-HSA-158956) PLAU(179-431) [plasma membrane] (R-HSA-158970) PLAU(21-431) [extracellular region] (R-HSA-158979) PLAU(21-431) [specific granule membrane] (R-HSA-6799705) PLAU(21-431) [plasma membrane] (R-HSA-158945) PLAU(21-431) [tertiary granule membrane] (R-HSA-6800974)	0.59	2
ChEBI:28304 HEPARIN			0.564	2
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9UMX0-2 UBQLN1			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3
UniProt:P78337 PITX1			0.556	3
UniProt:O43711 TLX3			0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:P02763 ORM1	4	ORM1 [platelet alpha granule lumen] (R-HSA-8848906) ORM1 [specific granule lumen] (R-HSA-6799632) ORM1 [extracellular region] (R-HSA-6799687) ORM1 [tertiary granule lumen] (R-HSA-6801026)	0.537	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10

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