SULT1A1 dimer sulfonates NHABP

Stable Identifier
R-HSA-158860
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
N-hydroxy-4-aminobiphenyl can form a sulfate conjugate
ReviewStatus
5/5
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SULT1A1 dimer sulfonates NHABP
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N-hydroxy-4-aminobiphenyl (NHABP) is a genotoxic metabolite of an industrial carcinogen no longer used in the rubber industry. It can be sulfonated in the liver by cytosolic sulfotransferase 1A1 (SULT1A1) (Yamazoe et al. 1999, Weinshilboum et al. 1997, Strott 2002).
Literature References
PubMed ID Title Journal Year
9034160 Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes

Weinshilboum, RM, Otterness, DM, Aksoy, IA, Wood, TC, Her, C, Raftogianis, RB

FASEB J 1997
12372849 Sulfonation and molecular action

Strott, CA

Endocr Rev 2002
10503886 Sulfotransferase catalyzing sulfation of heterocyclic amines

Yamazoe, Y, Nagata, K, Yoshinari, K, Fujita, K, Shiraga, T, Iwasaki, K

Cancer Lett 1999
Participants
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Output
Participates
as an event of
Catalyst Activity

aryl sulfotransferase activity of SULT1A1 dimer [cytosol]

Physical Entity
SULT1A1 dimer [cytosol] (Homo sapiens)
Activity
aryl sulfotransferase activity (GO:0004062)
Orthologous Events
SULT1A1 dimer sulfonates NHABP (Bos taurus)
SULT1A1 dimer sulfonates NHABP (Canis familiaris)
SULT1A1 dimer sulfonates NHABP (Danio rerio)
SULT1A1 dimer sulfonates NHABP (Gallus gallus)
SULT1A1 dimer sulfonates NHABP (Mus musculus)
SULT1A1 dimer sulfonates NHABP (Rattus norvegicus)
SULT1A1 dimer sulfonates NHABP (Sus scrofa)
SULT1A1 dimer sulfonates NHABP (Xenopus tropicalis)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2005-02-10)
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