Reactome | SERPINB2 [extracellular region]

SERPINB2 [extracellular region]

Stable Identifier

R-HSA-158997

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

plasminogen activator inhibitor 2, placental plasminogen activator inhibitor, PAI-2

Locations in the PathwayBrowser for interactor UniProt:P36507 MAP2K2

Expand all

External Reference Information

External Reference

UniProt:P05120 SERPINB2

Gene Names

SERPINB2, PAI2, PLANH2

Chain

chain:1-415, signal peptide:1-

Reference Genes

BioGPS Gene:5055 SERPINB2

COSMIC (genes):SERPINB2 SERPINB2

CTD Gene:5055 SERPINB2

dbSNP Gene:5055 SERPINB2

ENSEMBL:ENSG00000197632 SERPINB2

ENSEMBL_homo_sapiens_GENE:ENSG00000197632.9 SERPINB2

HGNC:8584 SERPINB2

KEGG Gene (Homo sapiens):5055 SERPINB2

Monarch:5055 SERPINB2

NCBI Gene:5055 SERPINB2

OMIM:173390 SERPINB2

UCSC:P05120 SERPINB2

Reference Transcript

Other Identifiers

11716631_s_at

16852871

204614_PM_at

204614_at

37185_at

3791938

3791941

3791942

3791945

3791946

3791948

3791949

3791951

3791952

3791953

3791954

3791955

3791956

3791957

5055

8021635

A_23_P153185

A_24_P245379

GE60232

GO:0001533

GO:0004867

GO:0005576

GO:0005615

GO:0005737

GO:0005886

GO:0012501

GO:0030414

GO:0042060

GO:0042730

GO:0043066

GO:0098772

HMNXSV003024938

ILMN_2150851

ILMN_2150856

M31551_s_at

PH_hs_0004364

g4505594_3p_at

Participates

as an output of

Expression of Plasminogen activator inhibitor 2 (Homo sapiens)

as an input of

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)

Other forms of this molecule

SERPINB2 [plasma membrane]

Inferred To

Serpinb2 [extracellular region] (Mus musculus)

Serpinb2 [extracellular region] (Rattus norvegicus)

LOC281376 [extracellular region] (Bos taurus)

SERPINB2 [extracellular region] (Canis familiaris)

SERPINB2 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002566.1, NP_001137290.1

OpenTargets

ENSG00000197632

GeneCards

P05120

HPA

ENSG00000197632-SERPINB2

Ensembl

ENST00000299502, ENSP00000401645, ENSG00000197632, ENST00000457692, ENSP00000299502

PRO

P05120

Pharos - Targets

P05120

PDB

1JRR, 1BY7, 2ARQ, 2ARR

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00341 HDLBP	1	HDLBP [plasma membrane] (R-HSA-8858026)	0.527	2
UniProt:Q96ER9 MITOK			0.527	2
UniProt:Q8N0Z3 SPICE			0.527	2
UniProt:Q93052 LPP			0.527	2
UniProt:Q9BVL4 SELO			0.527	3
UniProt:Q96A49 SYAP1			0.527	2
UniProt:P43026 GDF5	1	GDF5(28-501) [extracellular region] (R-HSA-2396129)	0.527	2
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.527	2
UniProt:O75165 DNAJC13	3	DNAJC13 [secretory granule membrane] (R-HSA-6800951) DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [azurophil granule membrane] (R-HSA-6799140)	0.527	3
UniProt:Q15075 EEA1	1	EEA1 [endosome membrane] (R-HSA-187893)	0.527	2
UniProt:Q7LBC6 KDM3B	1	KDM3B [nucleoplasm] (R-HSA-3214397)	0.527	2
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2
UniProt:Q9NRY4 ARHGAP35	2	ARHGAP35 [cytosol] (R-HSA-195118) p-Y1105-ARHGAP35 [cytosol] (R-HSA-8849056)	0.527	2
UniProt:Q8WYA0 IFT81	2	IFT81 [cilium] (R-HSA-5617769) IFT81 [ciliary tip] (R-HSA-5625369)	0.527	2
UniProt:P22059 OSBP	1	OSBP [cytosol] (R-HSA-429725)	0.527	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.527	2
UniProt:P57076 CF298			0.527	2
UniProt:Q96DX4 RSPRY			0.527	2
UniProt:Q86WT1 IFT70A	2	TTC30A [ciliary tip] (R-HSA-5637966) TTC30A [cilium] (R-HSA-5637968)	0.527	2
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.527	2
UniProt:O75529 TAF5L	1	TAF5L [nucleoplasm] (R-HSA-212336)	0.527	2
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.527	3
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.527	2
UniProt:Q9BX46 RBM24			0.527	2
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	3
UniProt:P35219 CAH8			0.527	2

Cite Us!