As inferred from mouse, p38 MAPK phosphorylates PGC-1alpha (PPARGC1A). Because p38 MAPK is responsive to intracellular calcium, this reaction may couple exercise to mitochondrial biogenesis.Phosphorylated p38 MAPK is found in the nucleus (Chan et al. 2004, http://www.cellsignal.com/products/4511.html, inferred from mouse in Blanco-Aparicio et al. 1999). p38 MAPK alpha, beta, and gamma (but not delta) are found in skeletal muscle (Jiang et al. 1997). PPARGC1A (PGC-1alpha) is predominantly nuclear (Knutti et al. 2001). As inferred from rat, PPARGC1A may translocate from the cytosol to the nucleus during activation (Wright et al. 2007).
Torres, J, Blanco-Aparicio, C, Pulido, R
Little, JP, Gibala, MJ, Tarnopolsky, MA, Bishop, D, Safdar, A
Kralli, A, Kressler, D, Knutti, D
Geiger, PC, Han, DH, Wright, DC, Garcia-Roves, PM, Holloszy, JO, Jones, TE
McGee, SL, Gibala, MJ, Hargreaves, M, Howlett, KF, Garnham, AP, Snow, RJ
Feng, L, Han, J, di Padova, F, Gu, J, Zhao, M, Ulevitch, RJ, Jiang, Y, Gram, H, New, L
protein serine/threonine kinase activity of phospho-p38 alpha/beta/gamma MAPK [nucleoplasm]
© 2023 Reactome