NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter

Stable Identifier
R-HSA-1592236
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PGC-1alpha (PPARGC1A) binds NRF1 and coactivates genes regulated by NRF1 (Gleyzer et al. 2005, Vercauteren et al. 2008, inferred from mouse in Wu et al. 1999).

Literature References
PubMed ID Title Journal Year
15684387 Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

Gleyzer, N, Vercauteren, K, Scarpulla, RC

Mol Cell Biol 2005
10412986 Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z, Puigserver, P, Andersson, U, Zhang, C, Adelmant, G, Mootha, V, Troy, A, Cinti, S, Lowell, B, Scarpulla, RC, Spiegelman, BM

Cell 1999
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
Cite Us!