Reactome | Autocatalytic activation of proMMP2

Autocatalytic activation of proMMP2

Stable Identifier

R-HSA-1592278

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Cleaving the Asn66-Leu67 bond of MMP2 activates it sufficiently to allow autocleavage of the Asn109-Tyr110 bond (Okada et al. 1990, Strongin et al. 1993, Crabbe et al. 1994a, Atkinson et al. 1995, Sang et al. 1996). This activation is inhibited by endostatin (Nyberg et al. 2003). Residue numbering here refers to the UniProt canonical sequence.

Literature References

PubMed ID	Title	Journal	Year
8530478	Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes Atkinson, SJ, Cowell, S, Sato, H, Ward, RV, Butler, MJ, Crabbe, T, Reynolds, JJ, Seiki, M, Murphy, G	J Biol Chem	1995
8314771	Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2 Marmer, BL, Strongin, AY, Goldberg, GI, Grant, GA	J Biol Chem	1993