Initial activation of proMMP3

Stable Identifier
R-HSA-1592371
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Initial activation of proMMP3
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
proMMP3 is activated in a similar manner to pro MMP1 but by a large number of proteinases, including bacterial thermolysin, all cleaving within the region residues 51-56 (Woessner & Nagase 2000). This initiates autocatalysis and cleavage of the His99-Phe100 bond (Nagase et al. 1990, 1991). Residue numbering given here is based on the UniProt canonical sequence.
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of proMMP3 initial activators [extracellular region]

Physical Entity
proMMP3 initial activators [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Initial activation of proMMP3 (Bos taurus)
Initial activation of proMMP3 (Caenorhabditis elegans)
Initial activation of proMMP3 (Canis familiaris)
Initial activation of proMMP3 (Danio rerio)
Initial activation of proMMP3 (Gallus gallus)
Initial activation of proMMP3 (Mus musculus)
Initial activation of proMMP3 (Rattus norvegicus)
Initial activation of proMMP3 (Sus scrofa)
Initial activation of proMMP3 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-09)
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