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UPF3B [cytosol]
Stable Identifier
R-HSA-159258
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
hUpf3B, UPf3B
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF3 [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
UPF3B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BZI7 UPF3B
Gene Names
UPF3B, RENT3B, UPF3X
Chain
chain:1-483
Reference Genes
BioGPS Gene:65109 UPF3B
COSMIC (genes):UPF3B UPF3B
CTD Gene:65109 UPF3B
dbSNP Gene:65109 UPF3B
ENSEMBL:ENSG00000125351 UPF3B
ENSEMBL_homo_sapiens_GENE:ENSG00000125351.14 UPF3B
HGNC:20439 UPF3B
KEGG Gene (Homo sapiens):65109 UPF3B
Monarch:65109 UPF3B
NCBI Gene:65109 UPF3B
OMIM:300298 UPF3B
UCSC:Q9BZI7 UPF3B
Reference Transcript
RefSeq:NM_023010.3 UPF3B
RefSeq:NM_080632.2 UPF3B
Other Identifiers
11723549_a_at
11751257_a_at
17113635
218757_PM_s_at
218757_s_at
2893364
4019575
4019576
4019577
4019578
4019580
4019583
4019584
4019586
4019587
4019589
4019590
4019592
4019595
4019596
65109
80832_s_at
8174717
A_23_P45409
A_24_P310630
GE63060
GO:0000184
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0007420
GO:0016071
GO:0030154
GO:0031175
GO:0034451
GO:0035145
GO:0043025
GO:0043226
GO:0045666
GO:0045727
GO:0048856
GO:0051028
GO:1905746
HMNXSV003040332
HMNXSV003046631
ILMN_1798163
ILMN_2397627
PH_hs_0005757
TC0X001315.hg
g12711673_3p_a_at
Participates
as a member of
UPF3 [cytosol] (Homo sapiens)
as a component of
EJC [cytosol] (Homo sapiens)
Other forms of this molecule
UPF3B [nucleoplasm]
Inferred To
UPF3B [cytosol]
(Bos taurus)
UPF3B [cytosol]
(Dictyostelium discoideum)
UPF3B [cytosol]
(Gallus gallus)
UPF3B [cytosol]
(Sus scrofa)
Upf3b [cytosol]
(Mus musculus)
Upf3b [cytosol]
(Rattus norvegicus)
upf3 [cytosol]
(Schizosaccharomyces pombe)
upf3b [cytosol]
(Danio rerio)
UPF3 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of UPF3B [cytosol]
(Canis familiaris)
Ghost homologue of UPF3B [cytosol]
(Xenopus tropicalis)
Upf3 [cytosol]
(Drosophila melanogaster)
smg-4 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_075386.1
,
NP_542199.1
OpenTargets
ENSG00000125351
GeneCards
Q9BZI7
HPA
ENSG00000125351-UPF3B
Ensembl
ENSP00000245418
,
ENST00000276201
,
ENSP00000276201
,
ENST00000345865
,
ENSG00000125351
PRO
Q9BZI7
Pharos - Targets
Q9BZI7
Orphanet
17318
PDB
1UW4
,
2XB2
,
7NWU
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.914
10
UniProt:Q9HAU5 UPF2
1
UPF2 [cytosol]
(R-HSA-927799)
0.897
9
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.886
11
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.883
9
UniProt:P61326 MAGOH
1
MAGOH [nucleoplasm]
(R-HSA-156658)
0.773
7
UniProt:Q15287 RNPS1
2
RNPS1 [nucleoplasm]
(R-HSA-156778)
RNPS1 [cytosol]
(R-HSA-159256)
0.643
3
UniProt:O15234 CASC3
2
CASC3 [cytosol]
(R-HSA-927807)
CASC3 [nucleoplasm]
(R-HSA-8849148)
0.643
3
UniProt:Q92900-2 UPF1
0.527
2
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.527
2
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