Conjugation of carboxylic acids

Stable Identifier
R-HSA-159424
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Conjugation of carboxylic acids
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Xenobiotics and endogenous compounds containing carboxylate groups can be activated with coenzyme A to produce acyl-CoA thioesters and then conjugated with the amino groups of glycine or glutamine to form amide-linked conjugates. Clinically important substrates include benzoic acid, phenylacetic acid, and salicylic acid.
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Event Information
Go Biological Process
xenobiotic metabolic process (0006805)
Orthologous Events
Conjugation of carboxylic acids (Bos taurus)
Conjugation of carboxylic acids (Caenorhabditis elegans)
Conjugation of carboxylic acids (Canis familiaris)
Conjugation of carboxylic acids (Danio rerio)
Conjugation of carboxylic acids (Gallus gallus)
Conjugation of carboxylic acids (Mus musculus)
Conjugation of carboxylic acids (Rattus norvegicus)
Conjugation of carboxylic acids (Sus scrofa)
Conjugation of carboxylic acids (Xenopus tropicalis)
Authored
Jassal, B  (2005-03-10)
Created
Jassal, B  (2005-03-09)
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