ACSM2B-like proteins transform ST to ST-CoA

Stable Identifier
R-HSA-159567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
salicylate + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Salicylic acid and Coenzyme A react to form salicylate-CoA thioester
ReviewStatus
5/5
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ACSM2B-like proteins transform ST to ST-CoA
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Salicylate (ST) and ATP react with coenzyme A to form salicylate-CoA (ST-CoA), AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003).
Literature References
PubMed ID Title Journal Year
12616642 Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria

Vessey, DA, Lau, E, Kelley, M, Warren, RS

J Biochem Mol Toxicol 2003
5862532 Pharmacokinetics of salicylate elimination in man

Levy, G

J Pharm Sci 1965
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Catalyst Activity

CoA-ligase activity of ACSM2B-like proteins [mitochondrial matrix]

Physical Entity
ACSM2B-like proteins [mitochondrial matrix] (Homo sapiens)
Activity
CoA-ligase activity (GO:0016405)
Orthologous Events
ACSM2B-like proteins transform ST to ST-CoA (Bos taurus)
ACSM2B-like proteins transform ST to ST-CoA (Canis familiaris)
ACSM2B-like proteins transform ST to ST-CoA (Danio rerio)
ACSM2B-like proteins transform ST to ST-CoA (Gallus gallus)
ACSM2B-like proteins transform ST to ST-CoA (Mus musculus)
ACSM2B-like proteins transform ST to ST-CoA (Rattus norvegicus)
ACSM2B-like proteins transform ST to ST-CoA (Sus scrofa)
ACSM2B-like proteins transform ST to ST-CoA (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2005-03-11)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2005-03-11)
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