Reactome | VKORC1 [endoplasmic reticulum membrane]

VKORC1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-159746

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

vitamin K epoxide reductase 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9BQB6 VKORC1

Gene Names

VKORC1, VKOR, MSTP134, MSTP576, UNQ308/PRO351

Chain

chain:1-163

Reference Genes

BioGPS Gene:79001 VKORC1

COSMIC (genes):VKORC1 VKORC1

CTD Gene:79001 VKORC1

dbSNP Gene:79001 VKORC1

ENSEMBL:ENSG00000167397.15 VKORC1

HGNC:23663 VKORC1

KEGG Gene (Homo sapiens):79001 VKORC1

Monarch:79001 VKORC1

NCBI Gene:79001 VKORC1

OMIM:608547 VKORC1

UCSC:Q9BQB6 VKORC1

Reference Transcript

Other Identifiers

0005690070

11715579_a_at

16825956

217949_PM_s_at

217949_s_at

3688222

3688223

3688224

3688225

3688226

3688227

3688228

3688229

3688230

3688231

3688236

3688237

3688238

45283_at

79001

8000998

A_23_P100486

GE88535

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0006766

GO:0006805

GO:0007596

GO:0010243

GO:0014070

GO:0016020

GO:0016021

GO:0016491

GO:0016900

GO:0017187

GO:0030193

GO:0036211

GO:0042060

GO:0042373

GO:0043226

GO:0043231

GO:0046677

GO:0047057

GO:0047058

GO:0048038

GO:0048856

GO:0050820

GO:0060348

HMNXSV003020811

ILMN_1739946

ILMN_1786139

PH_hs_0016148

TC16002083.hg

g13124769_3p_a_at

Participates

as a component of

VKORC1 dimer [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Vkor [endoplasmic reticulum membrane] (Drosophila melanogaster)

vkorc1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Vkorc1 [endoplasmic reticulum membrane] (Mus musculus)

Vkorc1 [endoplasmic reticulum membrane] (Rattus norvegicus)

VKORC1 [endoplasmic reticulum membrane] (Bos taurus)

VKORC1 [endoplasmic reticulum membrane] (Canis familiaris)

VKORC1 [endoplasmic reticulum membrane] (Danio rerio)

VKORC1 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_996560.1, NP_076869.1, NP_001298240.1

Guide to Pharmacology - Targets

2645

OpenTargets

ENSG00000167397

ZINC target

Q9BQB6

PRO

Q9BQB6

PDB

6WV4, 6WV6, 6WVH, 6WV3, 6WV5, 6WV7

HPA

ENSG00000167397-VKORC1

GeneCards

Q9BQB6

Ensembl

ENST00000319788, ENSG00000167397, ENSP00000346969, ENSP00000326135, ENST00000394975, ENSP00000378426, ENST00000354895

Pharos - Targets

Q9BQB6

ZINC - Predictions - Purchasable

VKOR1_HUMAN

Orphanet

17339

HMDB Protein

HMDBP02242

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3