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MMP2(67-109) [extracellular region]
Stable Identifier
R-HSA-1604371
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MMP2 fragment 67-109, Matrix metalloproteinase-2, MMP2_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Autocatalytic activation of bound proMMP2 (Homo sapiens)
MMP2(67-109) [extracellular region] (Homo sapiens)
Autocatalytic activation of proMMP2 (Homo sapiens)
MMP2(67-109) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08253 MMP2
Gene Names
MMP2, CLG4A
Chain
signal peptide:1-29, propeptide:30-109, chain:110-660, chain:445-660
Reference Genes
BioGPS Gene:4313 MMP2
COSMIC (genes):MMP2 MMP2
CTD Gene:4313 MMP2
dbSNP Gene:4313 MMP2
ENSEMBL:ENSG00000087245 MMP2
ENSEMBL_homo_sapiens_GENE:ENSG00000087245.13 MMP2
HGNC:7166 MMP2
KEGG Gene (Homo sapiens):4313 MMP2
Monarch:4313 MMP2
NCBI Gene:4313 MMP2
OMIM:120360 MMP2
UCSC:P08253 MMP2
Reference Transcript
RefSeq:NM_001302509.1 MMP2
RefSeq:NM_001302510.1 MMP2
RefSeq:NM_001127891.2 MMP2
RefSeq:NM_001302508.1 MMP2
RefSeq:NM_004530.5 MMP2
Other Identifiers
11741377_a_at
11743250_a_at
11743251_s_at
11745767_a_at
16819062
16819064
201069_PM_at
201069_at
3661685
3661686
3661687
3661688
3661691
3661692
3661694
3661695
3661697
3661699
3661701
3661702
3661703
3661704
3661705
3661707
3661708
3661709
3661710
3661711
3661712
3661713
39007_at
4313
56572_at
7995681
A_14_P114963
A_21_P0009102
A_23_P163787
A_33_P3237135
GE79835
GE88806
GO:0001525
GO:0001541
GO:0001542
GO:0001553
GO:0001666
GO:0001955
GO:0001957
GO:0001968
GO:0002376
GO:0003013
GO:0003824
GO:0004175
GO:0004222
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005886
GO:0006508
GO:0006979
GO:0007155
GO:0007162
GO:0007507
GO:0007565
GO:0007566
GO:0007567
GO:0008233
GO:0008237
GO:0008270
GO:0009410
GO:0009612
GO:0012501
GO:0014012
GO:0014823
GO:0016020
GO:0016477
GO:0016787
GO:0019538
GO:0022414
GO:0022617
GO:0023052
GO:0030017
GO:0030154
GO:0030163
GO:0030198
GO:0030312
GO:0030335
GO:0030574
GO:0031012
GO:0032526
GO:0034097
GO:0034614
GO:0035094
GO:0035987
GO:0042542
GO:0043065
GO:0043226
GO:0043627
GO:0045906
GO:0046872
GO:0048013
GO:0048246
GO:0048661
GO:0048705
GO:0048771
GO:0048856
GO:0048870
GO:0050896
GO:0051602
GO:0055093
GO:0060325
GO:0060346
GO:0060740
GO:0062023
GO:0071230
GO:0071345
GO:0071347
GO:0071392
GO:0071492
GO:0071498
GO:0140096
GO:1903378
GO:1904645
GO:1904707
HMNXSV003033312
HMNXSV003036887
Hs2.367877.1.S1_3p_s_at
ILMN_1762106
M55593_at
PH_hs_0024052
TC16000454.hg
TC16001568.hg
TC16001569.hg
g11342665_3p_at
g11342665_3p_s_at
p20047
Participates
as an output of
Autocatalytic activation of proMMP2 (Homo sapiens)
Autocatalytic activation of bound proMMP2 (Homo sapiens)
Other forms of this molecule
MMP2(67-660) [extracellular region]
MMP2(30-66) [extracellular region]
MMP2(30-660) [extracellular region]
MMP2(110-660) [extracellular region]
Inferred To
Homologues of MMP2(67-109) [extracellular region]
(Caenorhabditis elegans)
Homologues of MMP2(67-109) [extracellular region]
(Drosophila melanogaster)
MMP2(67-109) [extracellular region]
(Bos taurus)
MMP2(67-109) [extracellular region]
(Caenorhabditis elegans)
MMP2(67-109) [extracellular region]
(Canis familiaris)
MMP2(67-109) [extracellular region]
(Danio rerio)
MMP2(67-109) [extracellular region]
(Drosophila melanogaster)
MMP2(67-109) [extracellular region]
(Gallus gallus)
MMP2(67-109) [extracellular region]
(Mus musculus)
MMP2(67-109) [extracellular region]
(Rattus norvegicus)
MMP2(67-109) [extracellular region]
(Sus scrofa)
MMP2(67-109) [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004521.1
,
NP_001121363.1
,
NP_001289439.1
,
NP_001289438.1
,
NP_001289437.1
ZINC - World Drugs
MMP2_HUMAN
Guide to Pharmacology - Targets
1629
OpenTargets
ENSG00000087245
ZINC - FDA approved
MMP2_HUMAN
ZINC - Substances
MMP2_HUMAN
ZINC - Biogenic
MMP2_HUMAN
ZINC target
P08253
PRO
P08253
PDB
1GXD
,
1HOV
,
1CK7
,
8H78
,
1KS0
,
1J7M
,
1GEN
,
1RTG
,
3AYU
,
1CXW
,
1QIB
,
7XJO
,
7XGJ
,
1EAK
ZINC - Investigational
MMP2_HUMAN
ZINC - Metabolites
MMP2_HUMAN
HPA
ENSG00000087245-MMP2
GeneCards
P08253
Ensembl
ENSP00000219070
,
ENSP00000394237
,
ENSG00000087245
,
ENSP00000444143
,
ENST00000543485
,
ENST00000219070
,
ENSP00000461421
,
ENST00000570308
,
ENST00000437642
Pharos - Targets
P08253
Orphanet
16453
ZINC - Predictions - Purchasable
MMP2_HUMAN
HMDB Protein
HMDBP02804
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20908 COL5A1
20
3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023553)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023664)
GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023513)
GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023628)
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023564)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023647)
COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022460)
3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022510)
3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022483)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022948)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022970)
5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022989)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268653)
COL5A1(38-1838) [extracellular region]
(R-HSA-2268703)
3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268718)
3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268664)
3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region]
(R-HSA-2268667)
GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268629)
5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268644)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268663)
0.716
4
UniProt:P16035 TIMP2
4
TIMP2 [specific granule lumen]
(R-HSA-6799625)
TIMP2 [ficolin-1-rich granule lumen]
(R-HSA-6800944)
TIMP2 [tertiary granule lumen]
(R-HSA-6800881)
TIMP2 [extracellular region]
(R-HSA-1454879)
0.688
3
UniProt:P05067-PRO_0000000092 APP
0.623
4
UniProt:Q8NBP7 PCSK9
5
PCSK9 [endolysosome membrane]
(R-HSA-6784823)
PCSK9 [lysosomal membrane]
(R-HSA-8855128)
PCSK9 [extracellular region]
(R-HSA-6784727)
p-PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956943)
PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956745)
0.618
4
IntAct:EBI-2325312 COLLAGEN
0.618
3
UniProt:Q04864-2 REL
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P08572 COL4A2
20
3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2023633)
3x4Hyp-3Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2023568)
3x4Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2023589)
3x4Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2023657)
GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2023517)
GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2023630)
COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-1980177)
3x4Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2022089)
3x4Hyp-3Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2022524)
3x4Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2022983)
3x4Hyp-3Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2022964)
5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen]
(R-HSA-2022478)
3,4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region]
(R-HSA-2682411)
4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region]
(R-HSA-2682409)
5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region]
(R-HSA-2682392)
GalHyl-COL4A2(26-?) [extracellular region]
(R-HSA-2468186)
3x4Hyp-3Hyp-GalHyl-COL4A2(26-?) [extracellular region]
(R-HSA-2468187)
3x4Hyp-GalHyl-COL4A2(?-1712) [extracellular region]
(R-HSA-2468184)
3x4Hyp-3Hyp-5Hyl-COL4A2(26-?) [extracellular region]
(R-HSA-2468185)
3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-?) [extracellular region]
(R-HSA-2468190)
0.527
2
UniProt:P12110 COL6A2
20
3x4Hyp-3Hyp-GalHyl-COL6A2(257-1019) [endoplasmic reticulum lumen]
(R-HSA-2023552)
3x4Hyp-GalHyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2023555)
GalHyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2187485)
GlcGalHyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2187483)
3x4Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2023675)
3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2023643)
COL6A2 [endoplasmic reticulum lumen]
(R-HSA-1614503)
3x4Hyp-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2022423)
3x4Hyp-3Hyp-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2022438)
3x4Hyp-5Hyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2022975)
3x4Hyp-3Hyp-5Hyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2022943)
5Hyl-COL6A2 [endoplasmic reticulum lumen]
(R-HSA-2023007)
GlcGalHyl-COL6A2(?-1019) [extracellular region]
(R-HSA-2470106)
3x4Hyp-GalHyl-COL6A2(21-?) [extracellular region]
(R-HSA-2470235)
COL6A2(?-1019) [extracellular region]
(R-HSA-2470168)
3x4Hyp-3Hyp-GalHyl-COL6A2(21-?) [extracellular region]
(R-HSA-2470142)
3x4Hyp-5Hyl-COL6A2(21-?) [extracellular region]
(R-HSA-2470175)
3x4Hyp-3Hyp-5Hyl-COL6A2(?-1019) [extracellular region]
(R-HSA-2470076)
3x4Hyp-3Hyp-5Hyl-COL6A2(21-?) [extracellular region]
(R-HSA-2470067)
COL6A2(21-?) [extracellular region]
(R-HSA-2470166)
0.527
2
UniProt:P35625 TIMP3
2
TIMP3 [extracellular region]
(R-HSA-1430774)
TIMP3 [platelet dense granule lumen]
(R-HSA-8848904)
0.527
2
UniProt:P12109 COL6A1
20
GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023521)
3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023651)
GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023608)
3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023576)
3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023560)
3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023660)
COL6A1 [endoplasmic reticulum lumen]
(R-HSA-1614453)
3x4Hyp-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022508)
3x4Hyp-3Hyp-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022507)
3x4Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022965)
3x4Hyp-3Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022944)
5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022997)
3x4Hyp-COL6A1(?-1028) [extracellular region]
(R-HSA-2470138)
COL6A1(?-1028) [extracellular region]
(R-HSA-2470040)
3x4Hyp-COL6A1(20-?) [extracellular region]
(R-HSA-2470073)
GalHyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470046)
3x4Hyp-5Hyl-COL6A1(?-1028) [extracellular region]
(R-HSA-2470143)
3x4Hyp-3Hyp-5Hyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470066)
GlcGalHyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470033)
3x4Hyp-3Hyp-GalHyl-COL6A1(?-1028) [extracellular region]
(R-HSA-2470103)
0.527
2
UniProt:Q5KU26 COLEC12
2
COLEC12 [endocytic vesicle membrane]
(R-HSA-2981044)
COLEC12 [plasma membrane]
(R-HSA-2187209)
0.527
2
UniProt:Q96M94 KLH15
0.527
2
UniProt:P02462 COL4A1
20
GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065761)
GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065733)
3x4Hyp-3Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065577)
3x4Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065690)
3x4Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065674)
3x4Hyp-3Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065631)
COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065778)
3x4Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065707)
3x4Hyp-3Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065624)
3x4Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065659)
3x4Hyp-3Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065589)
5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen]
(R-HSA-2065736)
5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region]
(R-HSA-2682404)
3,4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region]
(R-HSA-2682381)
4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region]
(R-HSA-2682393)
3x4Hyp-COL4A1(24-?) [extracellular region]
(R-HSA-2468122)
COL4A1(?-1669) [extracellular region]
(R-HSA-2468120)
3x4Hyp-GlcGalHyl-COL4A1(?-1669) [extracellular region]
(R-HSA-2468121)
COL4A1(24-?) [extracellular region]
(R-HSA-2468127)
3x4Hyp-3Hyp-5Hyl-COL4A1(24-?) [extracellular region]
(R-HSA-2468124)
0.527
2
UniProt:Q16777 H2AC20
13
K63polyUb-HIST2H2AC [nucleoplasm]
(R-HSA-6783299)
Ub-HIST2H2AC [nucleoplasm]
(R-HSA-6782532)
AcK6-HIST2H2AC [nucleoplasm]
(R-HSA-4568572)
Me2aR30-HIST2H2AC [nucleoplasm]
(R-HSA-5244562)
MeR30-HIST2H2AC [nucleoplasm]
(R-HSA-5244542)
Me2aR4-HIST2H2AC [nucleoplasm]
(R-HSA-5244589)
HIST2H2AC [nucleoplasm]
(R-HSA-181892)
AcK-HIST2H2AC [nucleoplasm]
(R-HSA-4551338)
HIST2H2AC [extracellular region]
(R-HSA-977563)
MeR12-HIST2H2AC [nucleoplasm]
(R-HSA-5229227)
Me2aR12-HIST2H2AC [nucleoplasm]
(R-HSA-5229306)
Me2sR4-HIST2H2AC [nucleoplasm]
(R-HSA-5218305)
MeR4-HIST2H2AC [nucleoplasm]
(R-HSA-5244625)
0.527
2
UniProt:Q14508 WFDC2
1
WFDC2 [extracellular region]
(R-HSA-9830363)
0.499
11
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