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CDK8:CCNC [nucleoplasm]
Stable Identifier
R-HSA-1604465
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
MAML in complex with NICD1 recruits CDK8 (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NICD1 is phosphorylated by CDK8 (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
Participants
components
CCNC [nucleoplasm]
(Homo sapiens)
CDK8 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)
MAML recruits CDK8:CCNC to xNICD1 (Homo sapiens)
MAML in complex with NICD1 recruits CDK8 (Homo sapiens)
as an output of
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
CDK8 phosphorylates xNICD1 (Homo sapiens)
NICD1 is phosphorylated by CDK8 (Homo sapiens)
as a component of
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
xNOTCH1 Chimeric Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
NOTCH1 Coactivator Complex:CDK8:CCNC [nucleoplasm] (Homo sapiens)
as a member of
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
Inferred To
CDK8:CCNC [nucleoplasm]
(Bos taurus)
CDK8:CCNC [nucleoplasm]
(Caenorhabditis elegans)
CDK8:CCNC [nucleoplasm]
(Canis familiaris)
CDK8:CCNC [nucleoplasm]
(Drosophila melanogaster)
CDK8:CCNC [nucleoplasm]
(Mus musculus)
CDK8:CCNC [nucleoplasm]
(Rattus norvegicus)
CDK8:CCNC [nucleoplasm]
(Sus scrofa)
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