Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
INPP5J [cytosol]
Stable Identifier
R-HSA-1604590
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PIB5PA, PIPP
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
INPP5(4) [cytosol] (Homo sapiens)
INPP5J [cytosol] (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
INPP5J [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
INPP5(2) [cytosol] (Homo sapiens)
INPP5J [cytosol] (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
SYNJ/INPP5(1) [cytosol] (Homo sapiens)
INPP5(1) [cytosol] (Homo sapiens)
INPP5J [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15735 INPP5J
Gene Names
INPP5J, PIB5PA, PIPP
Chain
chain:1-1006
Reference Genes
BioGPS Gene:27124 INPP5J
COSMIC (genes):INPP5J INPP5J
CTD Gene:27124 INPP5J
dbSNP Gene:27124 INPP5J
ENSEMBL:ENSG00000185133.14 INPP5J
HGNC:8956 INPP5J
KEGG Gene (Homo sapiens):27124 INPP5J
Monarch:27124 INPP5J
NCBI Gene:27124 INPP5J
OMIM:606481 INPP5J
UCSC:Q15735 INPP5J
Reference Transcript
RefSeq:NM_001284285.1 INPP5J
RefSeq:XM_017028771.1 INPP5J
RefSeq:NM_001284288.1 INPP5J
RefSeq:NM_001002837.2 INPP5J
RefSeq:NM_001284289.1 INPP5J
Other Identifiers
11723604_a_at
11746630_x_at
11750267_x_at
16929118
213651_PM_at
213651_at
27124
38960_at
3942767
3942768
3942769
3942770
3942771
3942773
3942774
3942775
3942776
3942777
3942778
3942779
3942780
3942781
3942784
3942786
3942788
3942790
3942791
3942793
3942794
3942797
3942799
3942800
3942801
3942802
8072436
A_14_P107045
A_24_P284805
GE59182
GO:0001726
GO:0003824
GO:0004439
GO:0004445
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006629
GO:0006661
GO:0007010
GO:0010977
GO:0016787
GO:0016791
GO:0017124
GO:0019637
GO:0030154
GO:0030426
GO:0031115
GO:0032587
GO:0033137
GO:0034485
GO:0036211
GO:0043198
GO:0043647
GO:0046855
GO:0046856
GO:0048856
GO:0052658
GO:0052659
GO:0065003
GO:0110165
HMNXSV003031176
Hs.21492.0.S1_3p_at
ILMN_1670668
ILMN_1777644
PH_hs_0031056
TC22001429.hg
U45975_at
Participates
as a member of
INPP5(4) [cytosol] (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
INPP5(2) [cytosol] (Homo sapiens)
INPP5(1) [cytosol] (Homo sapiens)
Inferred To
INPP5J [cytosol]
(Bos taurus)
INPP5J [cytosol]
(Canis familiaris)
INPP5J [cytosol]
(Danio rerio)
INPP5J [cytosol]
(Plasmodium falciparum)
INPP5J [cytosol]
(Schizosaccharomyces pombe)
INPP5J [cytosol]
(Sus scrofa)
Inpp5j [cytosol]
(Mus musculus)
Inpp5j [cytosol]
(Rattus norvegicus)
Dd5P2 [cytosol]
(Dictyostelium discoideum)
Dmel\CG9784 [cytosol]
(Drosophila melanogaster)
Dd5P4 [cytosol]
(Dictyostelium discoideum)
Homologues of INPP5J [cytosol]
(Dictyostelium discoideum)
Homologues of INPP5J [cytosol]
(Plasmodium falciparum)
INP54 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001271214.1
,
NP_001002837.1
,
NP_001271218.1
,
XP_016884260.1
,
NP_001271217.1
Guide to Pharmacology - Targets
1457
OpenTargets
ENSG00000185133
GeneCards
Q15735
HPA
ENSG00000185133-INPP5J
Ensembl
ENSG00000185133
,
ENSP00000384596
,
ENST00000405300
,
ENST00000404390
,
ENST00000331075
,
ENSP00000383150
,
ENST00000400294
,
ENSP00000384534
,
ENSP00000333262
PRO
Q15735
Pharos - Targets
Q15735
HMDB Protein
HMDBP00363
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.556
3
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text