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PIK3C2A [cytosol]
Stable Identifier
R-HSA-1604624
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, P3C2A_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q13492 PICALM
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PIK3C2A [cytosol] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PIK3C2A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00443 PIK3C2A
Gene Names
PIK3C2A
Chain
initiator methionine:, chain:2-1686
Reference Genes
BioGPS Gene:5286 PIK3C2A
COSMIC (genes):PIK3C2A PIK3C2A
CTD Gene:5286 PIK3C2A
dbSNP Gene:5286 PIK3C2A
ENSEMBL:ENSG00000011405 PIK3C2A
ENSEMBL_homo_sapiens_GENE:ENSG00000011405.14 PIK3C2A
HGNC:8971 PIK3C2A
KEGG Gene (Homo sapiens):5286 PIK3C2A
Monarch:5286 PIK3C2A
NCBI Gene:5286 PIK3C2A
OMIM:603601 PIK3C2A
UCSC:O00443 PIK3C2A
Reference Transcript
RefSeq:XM_017017924.1 PIK3C2A
RefSeq:NM_002645.3 PIK3C2A
RefSeq:NM_001321378.1 PIK3C2A
Other Identifiers
11722894_s_at
11722895_a_at
11722896_a_at
11756945_a_at
1553694_PM_a_at
1553694_a_at
1569022_PM_a_at
1569022_a_at
16736226
213070_PM_at
213070_at
226094_PM_at
226094_at
235792_3p_x_at
235792_PM_x_at
235792_x_at
3364760
3364761
3364762
3364763
3364770
3364772
3364773
3364774
3364775
3364776
3364777
3364778
3364779
3364780
3364781
3364782
3364785
3364788
3364789
3364790
3364791
3364792
3364793
3364794
3364795
3364801
3364802
3364804
3364805
3364806
3364807
3364808
3364817
3364818
3364819
3364821
3364823
3364826
3364827
3364828
3364832
36509_at
5286
76325_at
77866_at
7946815
A_23_P36166
A_33_P3231878
GE56221
GE81171
GO:0000166
GO:0003012
GO:0003013
GO:0003824
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005802
GO:0005829
GO:0005886
GO:0005942
GO:0006629
GO:0006661
GO:0006887
GO:0006897
GO:0006914
GO:0007173
GO:0008286
GO:0008289
GO:0010508
GO:0014829
GO:0016020
GO:0016192
GO:0016301
GO:0016303
GO:0016310
GO:0016740
GO:0023052
GO:0030136
GO:0030276
GO:0031410
GO:0031982
GO:0035005
GO:0035091
GO:0036092
GO:0043226
GO:0043231
GO:0043491
GO:0046854
GO:0046934
GO:0048008
GO:0048015
GO:0048268
GO:0048856
GO:0048870
GO:0061024
GO:0065003
GO:0070062
GO:0090050
HMNXSV003009371
Hs.207212.0.A1_3p_at
Hs.207212.0.A1_3p_s_at
Hs.249235.0.S2_3p_at
Hs.5848.0.S1_3p_at
Hs2.249235.1.S1_3p_s_at
ILMN_2166093
PH_hs_0013220
TC11003476.hg
Participates
as an output of
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
as a component of
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PIK3C2A:Ca2+/Mg2+ [cytosol] (Homo sapiens)
as an input of
Clathrin recruits PIK3C2A (Homo sapiens)
Other forms of this molecule
PIK3C2A [Golgi membrane]
PIK3C2A [cytoplasmic vesicle membrane]
Inferred To
pik3c2a [cytosol]
(Xenopus tropicalis)
pikB [cytosol]
(Dictyostelium discoideum)
pikG [cytosol]
(Dictyostelium discoideum)
Ghost homologue of PIK3C2A [cytosol]
(Caenorhabditis elegans)
PIK3C2A [cytosol]
(Bos taurus)
PIK3C2A [cytosol]
(Canis familiaris)
PIK3C2A [cytosol]
(Gallus gallus)
PIK3C2A [cytosol]
(Sus scrofa)
Pik3c2a [cytosol]
(Mus musculus)
Pik3c2a [cytosol]
(Rattus norvegicus)
pikF [cytosol]
(Dictyostelium discoideum)
Homologues of PIK3C2A [cytosol]
(Dictyostelium discoideum)
pikC [cytosol]
(Dictyostelium discoideum)
pikA [cytosol]
(Dictyostelium discoideum)
pikH [cytosol]
(Dictyostelium discoideum)
Pi3K68D [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016873413.1
,
NP_002636.2
,
NP_001308307.1
Guide to Pharmacology - Targets
2150
OpenTargets
ENSG00000011405
ZINC - Substances
P3C2A_HUMAN
ZINC target
O00443
PRO
O00443
PDB
6BUB
,
6BTZ
,
2RED
,
2AR5
,
2IWL
,
6BTY
,
2REA
,
6BU0
ZINC - Investigational
P3C2A_HUMAN
IntEnz
2.7.1.153
,
2.7.1.154
GeneCards
O00443
HPA
ENSG00000011405-PIK3C2A
Ensembl
ENSP00000265970
,
ENSG00000011405
,
ENST00000691414
,
ENST00000265970
,
ENSP00000509400
Pharos - Targets
O00443
ZINC - Predictions - Purchasable
P3C2A_HUMAN
HMDB Protein
HMDBP03120
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.745
6
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.644
5
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.643
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.569
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.569
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.569
3
UniProt:P09497 CLTB
5
CLTB [cytosol]
(R-HSA-8856819)
CLTB [trans-Golgi network membrane]
(R-HSA-5333645)
CLTB [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138428)
CLTB [lysosomal membrane]
(R-HSA-2980616)
CLTB [plasma membrane]
(R-HSA-2980617)
0.527
2
UniProt:Q15274 QPRT
1
QPRT [cytosol]
(R-HSA-197212)
0.527
3
UniProt:Q13492 PICALM
3
PICALM [cytosol]
(R-HSA-8867593)
PICALM [cytoplasmic vesicle membrane]
(R-HSA-429812)
PICALM [Golgi membrane]
(R-HSA-434341)
0.527
2
UniProt:Q96FJ0 STAMBPL1
1
STAMBPL1 [cytosol]
(R-HSA-6783264)
0.527
3
UniProt:Q96C01 F136A
0.527
3
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
UniProt:Q5SZD1 CF141
0.527
2
UniProt:Q8IV13 CCNJL
0.527
2
UniProt:Q9Y2S2 CRYL1
1
CRYL1 [cytosol]
(R-HSA-5661279)
0.527
2
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