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MTMR4 [cytosol]
Stable Identifier
R-HSA-1604658
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KIAA0647, ZFYVE11
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
MTMR4 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
MTMR4 [cytosol] (Homo sapiens)
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTMR4 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTMR4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA4 MTMR4
Gene Names
MTMR4, KIAA0647, ZFYVE11
Chain
chain:1-1195
Reference Genes
BioGPS Gene:9110 MTMR4
COSMIC (genes):MTMR4 MTMR4
CTD Gene:9110 MTMR4
dbSNP Gene:9110 MTMR4
ENSEMBL:ENSG00000108389 MTMR4
ENSEMBL_homo_sapiens_GENE:ENSG00000108389.10 MTMR4
HGNC:7452 MTMR4
KEGG Gene (Homo sapiens):9110 MTMR4
Monarch:9110 MTMR4
NCBI Gene:9110 MTMR4
OMIM:603559 MTMR4
UCSC:Q9NYA4 MTMR4
Reference Transcript
RefSeq:NM_004687.4 MTMR4
RefSeq:XM_005257786.4 MTMR4
RefSeq:XM_006722168.3 MTMR4
Other Identifiers
11717040_at
11717041_at
16847117
212277_PM_at
212277_at
214268_PM_s_at
214268_s_at
3764465
3764466
3764467
3764468
3764469
3764470
3764472
3764473
3764474
3764475
3764476
3764477
3764479
3764481
3764482
3764483
3764484
3764486
3764487
3764488
3764490
3764491
3764493
3764494
3764495
3764497
3764499
3764501
3764505
3764506
3764508
3764517
3764518
39707_at
8017019
9110
A_24_P382119
GE53358
GE80279
GO:0003824
GO:0004438
GO:0004721
GO:0004722
GO:0004725
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005829
GO:0006470
GO:0006629
GO:0006661
GO:0006914
GO:0010506
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0019903
GO:0023052
GO:0030512
GO:0031410
GO:0031901
GO:0036211
GO:0043226
GO:0046856
GO:0046872
GO:0052629
GO:0060304
GO:0140096
HMNXSV003028944
Hs.141727.0.A2_3p_at
Hs.141727.1.A1_3p_a_at
ILMN_1771019
PH_hs_0008374
TC17001734.hg
Participates
as a member of
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
Other forms of this molecule
MTMR4 [early endosome membrane]
Inferred To
YMR1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of MTMR4 [cytosol]
(Dictyostelium discoideum)
MTMR4 [cytosol]
(Bos taurus)
MTMR4 [cytosol]
(Canis familiaris)
MTMR4 [cytosol]
(Dictyostelium discoideum)
MTMR4 [cytosol]
(Drosophila melanogaster)
MTMR4 [cytosol]
(Gallus gallus)
MTMR4 [cytosol]
(Mus musculus)
MTMR4 [cytosol]
(Rattus norvegicus)
MTMR4 [cytosol]
(Schizosaccharomyces pombe)
MTMR4 [cytosol]
(Sus scrofa)
MTMR4 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_006722231.1
,
XP_005257843.1
,
NP_004678.3
OpenTargets
ENSG00000108389
GeneCards
Q9NYA4
HPA
ENSG00000108389-MTMR4
Ensembl
ENSG00000108389
,
ENST00000323456
,
ENSP00000325285
PRO
Q9NYA4
Pharos - Targets
Q9NYA4
HMDB Protein
HMDBP08922
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.706
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.615
4
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.615
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.615
4
UniProt:Q53EZ4 CEP55
0.527
2
UniProt:Q96IQ9 ZN414
0.527
2
UniProt:Q96LW9 ZSC31
0.527
2
UniProt:P09917 ALOX5
6
p-S272-ALOX5 [cytosol]
(R-HSA-265276)
ALOX5 [secretory granule lumen]
(R-HSA-6801306)
ALOX5 [extracellular region]
(R-HSA-6806468)
ALOX5 [ficolin-1-rich granule lumen]
(R-HSA-6801302)
ALOX5 [cytosol]
(R-HSA-429010)
p-S272-ALOX5 [nuclear envelope]
(R-HSA-2318765)
0.527
2
UniProt:Q9BUE0 MED18
1
MED18 [nucleoplasm]
(R-HSA-556826)
0.527
2
UniProt:Q16878 CDO1
1
CDO1 [cytosol]
(R-HSA-1614586)
0.527
2
UniProt:O14978 ZNF263
1
ZNF263 [nucleoplasm]
(R-HSA-1027393)
0.527
2
UniProt:Q8TCX5 RHPN1
1
RHPN1 [cytosol]
(R-HSA-5667017)
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:Q96HA8 NTAQ1
0.527
2
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
3
UniProt:Q96BR6 ZNF669
1
ZNF669 [nucleoplasm]
(R-HSA-2248869)
0.527
2
UniProt:Q86VS8 HOOK3
0.527
2
UniProt:Q8IXB1 DJC10
0.527
2
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.524
2
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.524
2
UniProt:Q8TDY2 RB1CC1
3
RB1CC1 [endoplasmic reticulum membrane]
(R-HSA-8948046)
p-RB1CC1 [cytosol]
(R-HSA-5675845)
RB1CC1 [cytosol]
(R-HSA-5333627)
0.483
2
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