Activation of MMP9 intermediate form by MMPs

Stable Identifier
R-HSA-1604690
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Activation of MMP9 intermediate form by MMPs
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The intermediate form of MMP9 is activated by cleavage of the Arg106-Phe107 peptide bond producing the fullly active 82-kDa MMP-9 species (Ogata et al. 1992, Fridman et al. 1995).
Literature References
PubMed ID Title Journal Year
1371271 Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9

Nagase, H, Ogata, Y, Enghild, JJ

J Biol Chem 1992
7780967 Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)

Peña, D, Fridman, R, Toth, M, Mobashery, S

Cancer Res 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP1 (2, 3, 7, 10, 13) [extracellular region]

Physical Entity
MMP1 (2, 3, 7, 10, 13) [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Activation of MMP9 intermediate form by MMPs (Bos taurus)
Activation of MMP9 intermediate form by MMPs (Caenorhabditis elegans)
Activation of MMP9 intermediate form by MMPs (Canis familiaris)
Activation of MMP9 intermediate form by MMPs (Drosophila melanogaster)
Activation of MMP9 intermediate form by MMPs (Gallus gallus)
Activation of MMP9 intermediate form by MMPs (Mus musculus)
Activation of MMP9 intermediate form by MMPs (Rattus norvegicus)
Activation of MMP9 intermediate form by MMPs (Sus scrofa)
Activation of MMP9 intermediate form by MMPs (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-19)
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