Initial activation of proMMP7 by trypsin

Stable Identifier
R-HSA-1604712
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Initial activation of proMMP7 by trypsin
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proMMP7 (proMatrilysin-1) activation by trypsin occurs via an intermediate cleaved at Lys50-Asn51 which undergoes autocatalysis (Crabbe et al. 1992). Leukocyte elastase and plasmin partially activate MMP7 by an uncharacterized mechanism. Highly sulfated glycosaminoglycans (GAG), such as heparin, chondroitin-4,6-sulfate (CS-E), and dermatan sulfate, markedly enhance (>50-fold) the intermolecular autolytic activation of promatrilysin and the activity of fully active matrilysin (Ra et al. 2009).
Literature References
PubMed ID Title Journal Year
1390635 Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases

Crabbe, T, Willenbrock, F, Eaton, D, Hynds, P, Carne, AF, Murphy, G, Docherty, AJ

Biochemistry 1992
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Catalyst Activity

serine-type endopeptidase activity of MMP7 initial activators [extracellular region]

Physical Entity
MMP7 initial activators [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Initial activation of proMMP7 by trypsin (Bos taurus)
Initial activation of proMMP7 by trypsin (Canis familiaris)
Initial activation of proMMP7 by trypsin (Gallus gallus)
Initial activation of proMMP7 by trypsin (Mus musculus)
Initial activation of proMMP7 by trypsin (Rattus norvegicus)
Initial activation of proMMP7 by trypsin (Sus scrofa)
Initial activation of proMMP7 by trypsin (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-19)
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