Reactome | Autocatalytic activation of MMP7

Autocatalytic activation of MMP7

Stable Identifier

R-HSA-1604763

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Once cleaved at Lys50-Asn51 MMP7 undergoes autocatalysis (Crabbe et al. 1992). Highly sulfated glycosaminoglycans (GAG), such as heparin, chondroitin-4,6-sulfate (CS-E), and dermatan sulfate, markedly enhance (>50-fold) the intermolecular autolytic activation of promatrilysin and the activity of fully active matrilysin (Ra et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
1390635	Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases Crabbe, T, Willenbrock, F, Eaton, D, Hynds, P, Carne, AF, Murphy, G, Docherty, AJ	Biochemistry	1992