Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SIRT3(?-399) [mitochondrial matrix]
Stable Identifier
R-HSA-1605416
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
SIRT3, NAD-dependent deacetylase sirtuin-3, mitochondrial, SIRT3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
SIRT3 deacetylates AcK-IDH2 dimer (Homo sapiens)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Homo sapiens)
SIRT3(?-399) [mitochondrial matrix] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of SIRT3 (Homo sapiens)
SIRT3(?-399) [mitochondrial matrix] (Homo sapiens)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Homo sapiens)
SIRT3(?-399) [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12186850
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
Schwer, B
,
North, BJ
,
Ott, M
,
Verdin, E
,
Frye, RA
J Cell Biol
2002
External Reference Information
External Reference
UniProt:Q9NTG7 SIRT3
Gene Names
SIRT3, SIR2L3
Chain
transit peptide:1-, chain:-399
Reference Genes
BioGPS Gene:23410 SIRT3
COSMIC (genes):SIRT3 SIRT3
CTD Gene:23410 SIRT3
dbSNP Gene:23410 SIRT3
ENSEMBL:ENSG00000142082 SIRT3
ENSEMBL_homo_sapiens_GENE:ENSG00000142082.15 SIRT3
HGNC:14931 SIRT3
KEGG Gene (Homo sapiens):23410 SIRT3
Monarch:23410 SIRT3
NCBI Gene:23410 SIRT3
OMIM:604481 SIRT3
UCSC:Q9NTG7 SIRT3
Reference Transcript
RefSeq:NM_001017524.2 SIRT3
RefSeq:XM_017017430.1 SIRT3
RefSeq:NM_012239.5 SIRT3
Other Identifiers
11722446_a_at
11722447_a_at
11739810_x_at
11739811_a_at
221562_PM_s_at
221562_s_at
221913_PM_at
221913_at
23410
3357786
3357789
3357790
3357796
3357798
3357801
3357804
3357805
3357810
3357811
3357812
3357813
3357815
49325_at
49327_PM_at
49327_at
7945357
A_23_P139265
A_24_P85158
A_24_P923684
GE58473
GO:0003677
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0006091
GO:0006325
GO:0006338
GO:0006476
GO:0006629
GO:0008270
GO:0009060
GO:0016740
GO:0016787
GO:0017136
GO:0019899
GO:0023052
GO:0032024
GO:0032991
GO:0033558
GO:0034979
GO:0034983
GO:0036211
GO:0043226
GO:0043565
GO:0046872
GO:0051287
GO:0070373
GO:0070403
GO:0140096
GO:1901671
GO:1902553
GO:2000304
GO:2000378
HMNXSV003049799
Hs.19306.1.S1_3p_s_at
ILMN_1724372
ILMN_1733985
PH_hs_0026684
TC11001228.hg
g13259626_3p_a_at
g13259626_3p_x_at
Participates
as an output of
Expression of SIRT3 (Homo sapiens)
as a component of
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
SIRT3 [nucleoplasm]
Inferred To
SIRT3(?-399) [mitochondrial matrix]
(Bos taurus)
SIRT3(?-399) [mitochondrial matrix]
(Canis familiaris)
SIRT3(?-399) [mitochondrial matrix]
(Dictyostelium discoideum)
SIRT3(?-399) [mitochondrial matrix]
(Gallus gallus)
SIRT3(?-399) [mitochondrial matrix]
(Mus musculus)
SIRT3(?-399) [mitochondrial matrix]
(Rattus norvegicus)
SIRT3(?-399) [mitochondrial matrix]
(Saccharomyces cerevisiae)
SIRT3(?-399) [mitochondrial matrix]
(Schizosaccharomyces pombe)
SIRT3(?-399) [mitochondrial matrix]
(Sus scrofa)
Homologues of SIRT3(?-399) [mitochondrial matrix]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001017524.1
,
XP_016872919.1
,
NP_036371.1
ZINC - World Drugs
SIR3_HUMAN
Guide to Pharmacology - Targets
2709
OpenTargets
ENSG00000142082
ZINC - FDA approved
SIR3_HUMAN
ZINC - Substances
SIR3_HUMAN
ZINC - Biogenic
SIR3_HUMAN
ZINC target
Q9NTG7
PRO
Q9NTG7
PDB
4FVT
,
8HLW
,
4JT8
,
4HD8
,
5Y4H
,
4JT9
,
4BN5
,
5D7N
,
3GLU
,
4BV3
,
8ANC
,
8HLY
,
4BN4
,
4O8Z
,
3GLT
,
4C78
,
3GLS
,
5Z93
,
8CCW
,
4BVH
,
5Z94
,
5BWN
,
4FZ3
,
4BVG
,
3GLR
,
4C7B
,
5BWO
,
8CCZ
,
5ZGC
,
8HN9
,
4BVF
,
8BBK
,
4BVE
,
5H4D
,
5YTK
,
4JSR
,
6ISO
,
4BVB
ZINC - Metabolites
SIR3_HUMAN
HPA
ENSG00000142082-SIRT3
GeneCards
Q9NTG7
Ensembl
ENSG00000142082
,
ENSP00000372191
,
ENSP00000437216
,
ENST00000529382
,
ENST00000382743
Pharos - Targets
Q9NTG7
ZINC - Predictions - Purchasable
SIR3_HUMAN
HMDB Protein
HMDBP08881
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10809 HSPD1
6
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.65
3
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.576
5
UniProt:P28799-2 GRN
0.556
3
UniProt:O60313 OPA1
4
OPA1 [mitochondrial inner membrane]
(R-HSA-5333636)
OPA1(195-960) [mitochondrial inner membrane]
(R-HSA-8867513)
OPA1(88-194) [mitochondrial inner membrane]
(R-HSA-8867509)
OPA1 [mitochondrial inner membrane]
(R-HSA-8867508)
0.544
3
UniProt:P25705 ATP5F1A
3
ATP5A1(1-553) [mitochondrial intermembrane space]
(R-HSA-1267978)
ATP5A1(1-553) [cytosol]
(R-HSA-1267955)
ATP5A1 [mitochondrial matrix]
(R-HSA-164575)
0.524
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text