Reactome | NEU3 [plasma membrane]

NEU3 [plasma membrane]

Stable Identifier

R-HSA-1605644

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sialidase-3, NEUR3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P09917 ALOX5

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
        
        NEU3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQ49 NEU3

Gene Names

NEU3

Chain

chain:1-428

Reference Genes

BioGPS Gene:10825 NEU3

COSMIC (genes):NEU3 NEU3

CTD Gene:10825 NEU3

dbSNP Gene:10825 NEU3

ENSEMBL:ENSG00000162139 NEU3

HGNC:7760 NEU3

KEGG:hsa:10825 NEU3

Monarch:10825 NEU3

NCBI Gene:10825 NEU3

OMIM:604617 NEU3

UCSC:Q9UQ49 NEU3

Reference Transcript

RefSeq:NM_006656.5 NEU3

Other Identifiers

10825

11735444_a_at

11735445_at

11752471_a_at

16729051

206948_PM_at

206948_at

216083_PM_s_at

216083_s_at

235474_PM_at

235474_at

31643_at

3340411

3340412

3340413

3340414

3340415

3340417

3340419

3340420

3340424

3340425

3340426

3340427

3340428

3340429

3340431

3340433

3340434

79355_at

7942562

82149_at

A_14_P106421

A_23_P203716

A_32_P125820

GE81665

GO:0003824

GO:0004308

GO:0005515

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0005901

GO:0005975

GO:0006629

GO:0006689

GO:0009313

GO:0009897

GO:0016020

GO:0016042

GO:0016787

GO:0016798

GO:0016997

GO:0031410

GO:0031901

GO:0043226

GO:0045742

GO:0046479

GO:0052794

GO:0052795

GO:0052796

GO:0055038

GO:1900186

GO:1901135

HMNXSV003055080

Hs.131365.0.A1_3p_at

Hs.225947.1.S1_3p_a_at

ILMN_1740524

PH_hs_0024848

TC11000797.hg

TC11000798.hg

TC11000799.hg

TC11000800.hg

TC11000801.hg

TC11002786.hg

g5803107_3p_at

Inferred To

neu3.3 [plasma membrane] (Danio rerio)

NEU3 [plasma membrane] (Bos taurus)

NEU3 [plasma membrane] (Canis familiaris)

NEU3 [plasma membrane] (Gallus gallus)

NEU3 [plasma membrane] (Mus musculus)

NEU3 [plasma membrane] (Rattus norvegicus)

NEU3 [plasma membrane] (Sus scrofa)

neu3 [plasma membrane] (Xenopus tropicalis)

Homologues of NEU3 [plasma membrane] (Danio rerio)

neu3.2 [plasma membrane] (Danio rerio)

neu3.5 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_006647.3

ENSEMBL

ENSG00000162139, ENSP00000432097, ENST00000294064, ENST00000531509, ENSP00000294064

OpenTargets

ENSG00000162139

ZINC - FDA approved

NEUR3_HUMAN

GeneCards

NEU3

HPA

ENSG00000162139-NEU3

ZINC - Substances

NEUR3_HUMAN

ZINC target

Q9UQ49

PRO

Q9UQ49

Pharos - Targets

Q9UQ49

ZINC - Predictions - Purchasable

NEUR3_HUMAN

HMDB Protein

HMDBP00319

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15496 PLA2G10	1	PLA2G10 [extracellular region] (R-HSA-1498793)	0.527	2
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [cytosol] (R-HSA-429010) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [secretory granule lumen] (R-HSA-6801306) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.527	2