Reactome | SMPD1 [lysosomal lumen]

SMPD1 [lysosomal lumen]

Stable Identifier

R-HSA-1605710

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Sphingomyelin phosphodiesterase, ASM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17405 SMPD1

Gene Names

SMPD1, ASM

Chain

signal peptide:1-46, chain:47-631, chain:254-631

Reference Genes

BioGPS Gene:6609 SMPD1

COSMIC (genes):SMPD1 SMPD1

CTD Gene:6609 SMPD1

dbSNP Gene:6609 SMPD1

ENSEMBL:ENSG00000166311 SMPD1

ENSEMBL_homo_sapiens_GENE:ENSG00000166311.10 SMPD1

HGNC:11120 SMPD1

KEGG Gene (Homo sapiens):6609 SMPD1

Monarch:6609 SMPD1

NCBI Gene:6609 SMPD1

OMIM:607608 SMPD1

UCSC:P17405 SMPD1

Reference Transcript

Other Identifiers

11717598_s_at

16721375

209420_PM_s_at

209420_s_at

216230_3p_x_at

216230_PM_x_at

216230_x_at

32574_at

3318683

3318684

3318685

3318686

3318687

3318688

3318689

3318690

3318693

3318694

3318696

3318697

6609

7938100

A_23_P203488

GE59855

GO:0001778

GO:0002376

GO:0003824

GO:0004767

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005768

GO:0005773

GO:0005811

GO:0005886

GO:0006629

GO:0006672

GO:0006684

GO:0006685

GO:0006687

GO:0007165

GO:0007399

GO:0008152

GO:0008203

GO:0008270

GO:0009410

GO:0009615

GO:0010212

GO:0012501

GO:0016192

GO:0016787

GO:0016798

GO:0023021

GO:0023052

GO:0031410

GO:0034340

GO:0034480

GO:0034612

GO:0034644

GO:0035307

GO:0036019

GO:0036211

GO:0042060

GO:0042220

GO:0042599

GO:0043065

GO:0043202

GO:0043226

GO:0043407

GO:0045807

GO:0046513

GO:0046598

GO:0046718

GO:0046872

GO:0048856

GO:0061024

GO:0061750

GO:0070062

GO:0070555

GO:0071277

GO:0098542

GO:0110165

GO:1901135

HMNXSV003035132

HMNXSV003035211

Hs.77813.2.S1_3p_s_at

ILMN_1741684

ILMN_1757370

M59916_at

PH_hs_0004492

TC11000131.hg

g179094_3p_a_at

Inferred To

Homologues of SMPD1 [lysosomal lumen] (Dictyostelium discoideum)

SMPD1 [lysosomal lumen] (Bos taurus)

SMPD1 [lysosomal lumen] (Caenorhabditis elegans)

SMPD1 [lysosomal lumen] (Canis familiaris)

SMPD1 [lysosomal lumen] (Dictyostelium discoideum)

SMPD1 [lysosomal lumen] (Drosophila melanogaster)

SMPD1 [lysosomal lumen] (Gallus gallus)

SMPD1 [lysosomal lumen] (Mus musculus)

SMPD1 [lysosomal lumen] (Rattus norvegicus)

SMPD1 [lysosomal lumen] (Sus scrofa)

SMPD1 [lysosomal lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001007594.2, NP_000534.3, XP_011518605.1, NP_001305016.1, NP_001305017.1

Guide to Pharmacology - Targets

2514

OpenTargets

ENSG00000166311

GeneCards

P17405

HPA

ENSG00000166311-SMPD1

ZINC target

P17405

Ensembl

ENSG00000166311, ENSP00000435350, ENST00000342245, ENST00000527275, ENSP00000340409

PRO

P17405

Pharos - Targets

P17405

Orphanet

15529

HMDB Protein

HMDBP00776

PDB

5I81, 5JG8, 5I85, 5I8R

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.537	6