Reactome | CTSA(29-326) [lysosomal lumen]

CTSA(29-326) [lysosomal lumen]

Stable Identifier

R-HSA-1605735

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

CTSA 32kDa chain, Cathepsin A, Lysosomal protective protein, PPGB_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Sphingolipid metabolism (Homo sapiens)
    - Glycosphingolipid metabolism (Homo sapiens)
      - Glycosphingolipid catabolism (Homo sapiens)
        
        NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Homo sapiens)
        
        NEU1,4 [lysosomal lumen] (Homo sapiens)
        
        NEU1:GLB1:CTSA dimer [lysosomal lumen] (Homo sapiens)
        
        CTSA dimer [lysosomal lumen] (Homo sapiens)
        
        CTSA(29-326) [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10619 CTSA

Gene Names

CTSA, PPGB

Chain

signal peptide:1-28, chain:29-480, chain:29-326, chain:327-480

Reference Genes

BioGPS Gene:5476 CTSA

COSMIC (genes):CTSA CTSA

CTD Gene:5476 CTSA

dbSNP Gene:5476 CTSA

ENSEMBL:ENSG00000064601 CTSA

HGNC:9251 CTSA

KEGG:hsa:5476 CTSA

Monarch:5476 CTSA

NCBI Gene:5476 CTSA

OMIM:613111 CTSA

UCSC:P10619 CTSA

Reference Transcript

Other Identifiers

11721499_x_at

11748622_s_at

16914352

200661_3p_at

200661_PM_at

200661_at

3887118

3887119

3887120

3887121

3887122

3887123

3887124

3887125

3887126

3887127

3887128

3887129

3887130

3887131

3887132

3887133

3887134

3887135

3887136

3887137

3887138

3887139

3887140

3887141

3887142

3887143

3887144

3887145

3887146

3887147

3887148

3887149

3887150

3887151

3887152

3887153

3887154

39062_at

5476

8063078

A_14_P119540

A_14_P135478

A_24_P74371

A_24_P74374

A_33_P3280213

GE56050

GE85531

GO:0003824

GO:0004180

GO:0004185

GO:0005576

GO:0005764

GO:0005773

GO:0005783

GO:0006508

GO:0006886

GO:0008047

GO:0016020

GO:0016787

GO:0031647

GO:0035578

GO:0043202

GO:0043226

GO:0043231

GO:0070062

GO:0098575

GO:0098772

GO:0140096

GO:1904714

GO:1904715

HMNXSV003021606

ILMN_1719286

M22960_at

PH_hs_0006486

TC20000361.hg

g4505988_3p_s_at

Participates

as a component of

CTSA dimer [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

CTSA(327-480) [azurophil granule lumen]

CTSA(29-326) [azurophil granule lumen]

CTSA(327-480) [extracellular region]

CTSA(29-326) [extracellular region]

CTSA(327-480) [lysosomal lumen]

CTSA(29-480) [lysosomal lumen]

Inferred To

CTSA(29-326) [lysosomal lumen] (Gallus gallus)

ctsa [lysosomal lumen] (Xenopus tropicalis)

Ctsa [lysosomal lumen] (Mus musculus)

Ctsa [lysosomal lumen] (Rattus norvegicus)

CTSA [lysosomal lumen] (Bos taurus)

CTSA [lysosomal lumen] (Canis familiaris)

CTSA [lysosomal lumen] (Sus scrofa)

Cross References

ZINC - World Drugs

PPGB_HUMAN

Guide to Pharmacology - Targets

1581

OpenTargets

ENSG00000064601

ENSEMBL

ENSP00000493613, ENSP00000346952, ENST00000191018, ENST00000372459, ENST00000607482, ENST00000646241, ENSP00000361537, ENSP00000191018, ENST00000354880, ENSP00000475524

ZINC - FDA approved

PPGB_HUMAN

ZINC - Substances

PPGB_HUMAN

ZINC target

P10619

PRO

P10619

GlyGen

P10619

PDB

3BP7, 4MWT, 4AZ3, 1IVY, 4MWS, 6WIA, 3BXN, 3BP4, 4CIB, 4AZ0, 4CIA, 4CI9

HPA

ENSG00000064601-CTSA

Pharos - Targets

P10619

Orphanet

CTSA

ZINC - Predictions - Purchasable

PPGB_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.643	4
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.508	2