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NEU2 [cytosol]
Stable Identifier
R-HSA-1605759
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Sialidase-2, NEUR2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9BY89 K1671
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid catabolism (Homo sapiens)
NEU2 cleaves GM3 to form LacCer (cytosol) (Homo sapiens)
NEU2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Sialic acid metabolism (Homo sapiens)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
NEU2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y3R4 NEU2
Gene Names
NEU2
Chain
chain:1-380
Reference Genes
BioGPS Gene:4759 NEU2
COSMIC (genes):NEU2 NEU2
CTD Gene:4759 NEU2
dbSNP Gene:4759 NEU2
ENSEMBL:ENSG00000115488 NEU2
HGNC:7759 NEU2
KEGG:hsa:4759 NEU2
Monarch:4759 NEU2
NCBI Gene:4759 NEU2
OMIM:605528 NEU2
UCSC:Q9Y3R4 NEU2
Reference Transcript
RefSeq:NM_005383.2 NEU2
Other Identifiers
11735974_at
16892443
221368_PM_at
221368_at
2532683
2532684
2532685
2532686
4759
8049243
A_23_P90980
GE565077
GO:0003824
GO:0004308
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005975
GO:0006516
GO:0006629
GO:0006689
GO:0009313
GO:0016020
GO:0016042
GO:0016787
GO:0016798
GO:0030163
GO:0043226
GO:0046479
GO:0052794
GO:0052795
GO:0052796
GO:1901135
GO:1902494
HMNXSV003043638
ILMN_1752557
PH_hs_0013168
TC02001413.hg
g4885514_3p_at
Inferred To
neu4 [cytosol]
(Danio rerio)
neu4 [cytosol]
(Xenopus tropicalis)
NEU2 [cytosol]
(Bos taurus)
NEU2 [cytosol]
(Canis familiaris)
NEU2 [cytosol]
(Gallus gallus)
NEU2 [cytosol]
(Mus musculus)
NEU2 [cytosol]
(Rattus norvegicus)
NEU2 [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
3258
OpenTargets
ENSG00000115488
ENSEMBL
ENST00000233840
,
ENSP00000233840
HPA
ENSG00000115488-NEU2
ZINC - Substances
NEUR2_HUMAN
ZINC target
Q9Y3R4
PRO
Q9Y3R4
Pharos - Targets
Q9Y3R4
ZINC - Predictions - Purchasable
NEUR2_HUMAN
PDB
2F0Z
,
2F28
,
2F29
,
2F27
,
2F26
,
4NC5
,
2F25
,
1SO7
,
2F13
,
2F10
,
2F24
,
2F12
,
2F11
,
1VCU
,
1SNT
,
4NCS
HMDB Protein
HMDBP00317
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.718
6
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q9UM47 NOTCH3
20
Ub-NICD3 [cytosol]
(R-HSA-9021546)
Ub-NEXT3 [plasma membrane]
(R-HSA-9021545)
p-Y-NICD3 [cytosol]
(R-HSA-9018581)
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911429)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911419)
NOTCH3(1572-2321) [Golgi membrane]
(R-HSA-156995)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
(R-HSA-1983672)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
(R-HSA-1983675)
NOTCH3(1572-2321) [plasma membrane]
(R-HSA-157231)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
(R-HSA-1472871)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467307)
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467382)
Pre-NOTCH3 [endoplasmic reticulum membrane]
(R-HSA-157102)
NICD3 [nucleoplasm]
(R-HSA-157928)
NICD3 [cytosol]
(R-HSA-157647)
NEXT3 [plasma membrane]
(R-HSA-157203)
NOTCH3(1629-1661) [plasma membrane]
(R-HSA-157657)
NOTCH3(40-1628) [extracellular region]
(R-HSA-157639)
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
(R-HSA-1911522)
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
(R-HSA-1911517)
0.527
3
UniProt:Q2TBE0 CWF19L2
1
CWF19L2 [nucleoplasm]
(R-HSA-9770846)
0.527
2
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.527
2
UniProt:P04844 RPN2
1
RPN2 [endoplasmic reticulum membrane]
(R-HSA-264937)
0.527
2
UniProt:Q9Y314 NOSIP
2
NOSIP [Golgi membrane]
(R-HSA-535001)
NOSIP [cytosol]
(R-HSA-203636)
0.527
2
UniProt:O95229 ZWINT
1
ZWINT [cytosol]
(R-HSA-376254)
0.527
2
UniProt:Q9BY89 K1671
0.527
3
UniProt:Q01664 TFAP4
0.527
2
UniProt:Q96Q83 ALKBH3
1
ALKBH3 [nucleoplasm]
(R-HSA-113682)
0.527
2
UniProt:Q9NTX9 F217B
0.527
2
UniProt:Q9UKA2 FBXL4
1
FBXL4 [cytosol]
(R-HSA-8850899)
0.527
2
UniProt:Q9NU19 TB22B
0.527
2
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