Reactome | HEXA [lysosomal lumen]

HEXA [lysosomal lumen]

Stable Identifier

R-HSA-1605799

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Beta-hexosaminidase subunit alpha, HEXA_HUMAN

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External Reference Information

External Reference

UniProt:P06865 HEXA

Gene Names

HEXA

Chain

signal peptide:1-22, propeptide:23-88, chain:89-529

Reference Genes

BioGPS Gene:3073 HEXA

COSMIC (genes):HEXA HEXA

CTD Gene:3073 HEXA

dbSNP Gene:3073 HEXA

ENSEMBL:ENSG00000213614 HEXA

HGNC:4878 HEXA

KEGG Gene (Homo sapiens):3073 HEXA

Monarch:3073 HEXA

NCBI Gene:3073 HEXA

OMIM:606869 HEXA

UCSC:P06865 HEXA

Reference Transcript

Other Identifiers

0007050685

11716888_s_at

11756829_x_at

11760303_x_at

11760537_x_at

16811437

201765_s_at

243511_at

3073

3632163

3632164

3632165

3632166

3632167

3632168

3632169

3632170

3632171

3632172

3632175

3632178

3632179

3632181

3632183

3632184

3632185

3632187

3632189

3632190

3632193

3632196

3632209

3632210

39340_at

48251_at

62860_at

7990211

A_19_P00803285

GE79844

GO:0003674

GO:0004553

GO:0004563

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005975

GO:0006024

GO:0006629

GO:0006687

GO:0006689

GO:0006790

GO:0008150

GO:0008152

GO:0008375

GO:0009056

GO:0009058

GO:0016020

GO:0016757

GO:0016787

GO:0016798

GO:0030207

GO:0030214

GO:0031410

GO:0034641

GO:0042340

GO:0042582

GO:0043202

GO:0043226

GO:0043231

GO:0044281

GO:0046982

GO:0070062

GO:0102148

HMNXSV003054347

Hs.119403.0.A1_3p_a_at

Hs.149332.0.A1_3p_at

ILMN_1813911

M16424_at

PH_hs_0019542

TC15002611.hg

TC15002779.hg

Participates

as a component of

HEXA [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

HEXA Y427Ifs*5 [lysosomal lumen]

Inferred To

Hexa [lysosomal lumen] (Mus musculus)

Hexa [lysosomal lumen] (Rattus norvegicus)

hexb2 [lysosomal lumen] (Dictyostelium discoideum)

HEXA [lysosomal lumen] (Bos taurus)

HEXA [lysosomal lumen] (Dictyostelium discoideum)

HEXA [lysosomal lumen] (Gallus gallus)

hexa2 [lysosomal lumen] (Dictyostelium discoideum)

hexa [lysosomal lumen] (Danio rerio)

hexb1 [lysosomal lumen] (Dictyostelium discoideum)

Hexo1 [lysosomal lumen] (Drosophila melanogaster)

hexa1 [lysosomal lumen] (Dictyostelium discoideum)

Homologues of HEXA [lysosomal lumen] (Dictyostelium discoideum)

Homologues of HEXA [lysosomal lumen] (Drosophila melanogaster)

fdl [lysosomal lumen] (Drosophila melanogaster)

hex-1 [lysosomal lumen] (Caenorhabditis elegans)

Hexo2 [lysosomal lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_000511.2, NP_001305754.1

OpenTargets

ENSG00000213614

ZINC - Substances

HEXA_HUMAN

ZINC target

P06865

PRO

P06865

GlyGen

P06865

PDB

2GJX, 2GK1

IntEnz

3.2.1.52

GeneCards

P06865

HPA

ENSG00000213614-HEXA

Ensembl

ENSG00000213614, ENST00000268097, ENSP00000268097

Pharos - Targets

P06865

ZINC - Predictions - Purchasable

HEXA_HUMAN

Orphanet

16193

HMDB Protein

HMDBP00872

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07686 HEXB	10	HEXB S62L [lysosomal lumen] (R-HSA-3700901) HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(315-556) [lysosomal lumen] (R-HSA-1605605) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843)	0.59	3