Reactome | SMPD3 [plasma membrane]

SMPD3 [plasma membrane]

Stable Identifier

R-HSA-1606265

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sphingomyelin phosphodiesterase 3, NSMA2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NY59 SMPD3

Gene Names

SMPD3

Chain

chain:1-655

Reference Genes

BioGPS Gene:55512 SMPD3

COSMIC (genes):SMPD3 SMPD3

CTD Gene:55512 SMPD3

dbSNP Gene:55512 SMPD3

ENSEMBL:ENSG00000103056 SMPD3

HGNC:14240 SMPD3

KEGG:hsa:55512 SMPD3

Monarch:55512 SMPD3

NCBI Gene:55512 SMPD3

OMIM:605777 SMPD3

UCSC:Q9NY59 SMPD3

Reference Transcript

Other Identifiers

11726509_at

11726510_a_at

16827606

219695_PM_at

219695_at

231732_PM_at

231732_at

3696318

3696319

3696320

3696321

3696322

3696323

3696324

3696325

3696326

3696327

3696328

3696329

3696330

3696331

3696332

3696333

3696334

3696340

3696350

49880_at

55512

8002249

A_23_P163567

A_23_P347027

A_33_P3397180

GE82435

GE88582

GO:0000137

GO:0000139

GO:0001501

GO:0001503

GO:0001786

GO:0001932

GO:0001958

GO:0002063

GO:0002244

GO:0002685

GO:0003433

GO:0003824

GO:0004767

GO:0005515

GO:0005576

GO:0005737

GO:0005794

GO:0005886

GO:0006629

GO:0006665

GO:0006672

GO:0006684

GO:0006685

GO:0007165

GO:0008081

GO:0008289

GO:0015774

GO:0016020

GO:0016787

GO:0030072

GO:0030154

GO:0030198

GO:0030282

GO:0030324

GO:0030509

GO:0032963

GO:0034614

GO:0035264

GO:0042802

GO:0043226

GO:0045840

GO:0046872

GO:0048008

GO:0048286

GO:0048661

GO:0048856

GO:0051216

GO:0051898

GO:0060348

GO:0060541

GO:0061035

GO:0061751

GO:0070300

GO:0070301

GO:0070314

GO:0071286

GO:0071356

GO:0071461

GO:0071897

GO:0085029

GO:0090520

GO:0097187

GO:0098868

GO:0140014

GO:0140052

GO:1900125

GO:1900126

GO:1901653

GO:1903543

HMNXSV003009923

HMNXSV003037180

Hs.283616.0.S1_3p_at

ILMN_1802316

ILMN_1804170

PH_hs_0014652

TC16001211.hg

g13375992_3p_at

Participates

as a member of

SMPD2,3 [plasma membrane] (Homo sapiens)

Inferred To

Homologues of SMPD3 [plasma membrane] (Dictyostelium discoideum)

smpd3 [plasma membrane] (Danio rerio)

smpd3 [plasma membrane] (Xenopus tropicalis)

SMPD3 [plasma membrane] (Bos taurus)

SMPD3 [plasma membrane] (Canis familiaris)

SMPD3 [plasma membrane] (Dictyostelium discoideum)

SMPD3 [plasma membrane] (Gallus gallus)

SMPD3 [plasma membrane] (Mus musculus)

SMPD3 [plasma membrane] (Plasmodium falciparum)

SMPD3 [plasma membrane] (Rattus norvegicus)

SMPD3 [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2516

ENSEMBL

ENST00000563226, ENSG00000103056, ENSP00000455955, ENSP00000219334, ENST00000219334

OpenTargets

ENSG00000103056

IntEnz

3.1.4.12

GeneCards

SMPD3

HPA

ENSG00000103056-SMPD3

PRO

Q9NY59

Pharos - Targets

Q9NY59

HMDB Protein

HMDBP06631

PDB

5UVG

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.527	2
UniProt:P04114 APOB	20	APOB(28-2179) [cytosol] (R-HSA-2395786) APOB(28-2179) [early endosome] (R-HSA-2429651) APOB(28-4563) [lysosomal lumen] (R-HSA-8876369) APOB(28-2179) [endosome lumen] (R-HSA-174716) APOB(28-2179) [endosome membrane] (R-HSA-174762) APOB(28-4563) [plasma membrane] (R-HSA-171089) APOB(28-4563) [clathrin-coated endocytic vesicle membrane] (R-HSA-171155) APOB(28-4563) [endosome lumen] (R-HSA-171119) APOB(28-4563) [endosome membrane] (R-HSA-171121) APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (R-HSA-174788) APOB(28-2179) [plasma membrane] (R-HSA-174625) APOB(28-4563) [extracellular region] (R-HSA-171065) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [extracellular region] (R-HSA-2173702) APOB(28-4563) [endoplasmic reticulum membrane] (R-HSA-6784882) p-APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-8957068) AcK-APOB(28-4563) [extracellular region] (R-HSA-2173751) AcK-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239446) APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2512789) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239461) APOB(28-4563) [smooth endoplasmic reticulum] (R-HSA-8866317)	0.527	2

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