Reactome | ARSC hydrolyzes steroid sulfates

ARSC hydrolyzes steroid sulfates

Stable Identifier

R-HSA-1606839

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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Steryl sulfatase (formerly arylsulfatase C, ARSC) hydrolyses sulfate from steroid sulfates (Noel et al. 1983, Vaccaro et al. 1987, Suzuki et al. 1992). It is located on the ER membrane (Stein et al. 1989) and functions as a homodimer, using calcium as a cofactor. Defects in STS are the cause of ichthyosis X-linked (IXL) (MIM:308100), a keratinisation disorder (Basler et al. 1992, Alperin & Shapiro 1997).

Literature References

PubMed ID	Title	Journal	Year
1539590	Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis Basler, E, Ballabio, A, Grompe, M, Parenti, G, Yates, J	Am J Hum Genet	1992
2953589	Purification and properties of arylsulfatase C from human placenta Muscillo, M, Renola, L, Salvioli, R, Vaccaro, AM	Enzyme	1987
2668275	Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells Stein, C, Rijnbout, S, Seidel, J, Hille, A, von Figura, K, Geuze, H, Waheed, A, Schmidt, B	J Biol Chem	1989
6417417	Human placental steroid sulfatase: purification and properties Bleau, G, Roberts, KD, Plante, L, Noël, H, Chapdelaine, A	J Steroid Biochem	1983
1606923	Purification and properties of steroid sulfatase from human placenta Yanaihara, N, Yanaihara, T, Sato, T, Hirato, K, Hoshino, M, Suzuki, T, Kadofuku, T	Endocrinol Jpn	1992
9252398	Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein Alperin, ES, Shapiro, LJ	J Biol Chem	1997