Reactome | SUMF1 [endoplasmic reticulum lumen]

SUMF1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-1614316

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Sulfatase-modifying factor 1, SUMF1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96EG1 ARSG

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External Reference Information

External Reference

UniProt:Q8NBK3 SUMF1

Gene Names

SUMF1, PSEC0152, UNQ3037/PRO9852

Chain

signal peptide:1-33, chain:34-374

Reference Genes

BioGPS Gene:285362 SUMF1

COSMIC (genes):SUMF1 SUMF1

CTD Gene:285362 SUMF1

dbSNP Gene:285362 SUMF1

ENSEMBL:ENSG00000144455 SUMF1

HGNC:20376 SUMF1

KEGG:hsa:285362 SUMF1

Monarch:285362 SUMF1

NCBI Gene:285362 SUMF1

OMIM:607939 SUMF1

UCSC:Q8NBK3 SUMF1

Reference Transcript

Other Identifiers

100130207

11720731_a_at

11720732_a_at

11747815_a_at

11760860_at

16950269

226850_PM_at

226850_at

2660803

2660804

2660805

2660806

2660807

2660822

2660823

2660824

2660826

2660827

2660828

2660831

2660832

2660833

2660834

2660838

2660839

2660840

2660841

2660864

2660884

2660885

2660886

2660887

2660888

2660889

2660891

2660892

2660894

2660895

2660896

2660898

2660899

2660902

2660903

2660904

2660905

2660907

2660908

285362

52973_at

8085094

ADDON001353.hg

A_33_P3219711

GE555731

GO:0005515

GO:0005783

GO:0005788

GO:0006629

GO:0016020

GO:0016491

GO:0018158

GO:0042802

GO:0043687

GO:0046479

GO:0046872

GO:0120147

GO:1901135

GO:1903135

HMNXSV003030767

HMNXSV003036233

HMNXSV003049240

HMNXSV003052584

Hs.302267.1.S1_3p_at

ILMN_1753472

PH_hs_0029816

TC03001125.hg

TC03001126.hg

TC03002780.hg

Participates

as an input of

SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)

as a component of

SUMF1:SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)

Inferred To

Dmel\CG7049 [endoplasmic reticulum lumen] (Drosophila melanogaster)

SUMF1 [endoplasmic reticulum lumen] (Bos taurus)

SUMF1 [endoplasmic reticulum lumen] (Canis familiaris)

SUMF1 [endoplasmic reticulum lumen] (Gallus gallus)

SUMF1 [endoplasmic reticulum lumen] (Sus scrofa)

sumf1 [endoplasmic reticulum lumen] (Danio rerio)

sumf1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Sumf1 [endoplasmic reticulum lumen] (Mus musculus)

Sumf1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_877437.2, NP_001158146.1, NP_001158147.1

OpenTargets

ENSG00000144455

ENSEMBL

ENST00000405420, ENSP00000373355, ENST00000272902, ENST00000383843, ENSP00000384977, ENSP00000272902, ENSG00000144455

HPA

ENSG00000144455-SUMF1

GeneCards

SUMF1

PRO

Q8NBK3

Pharos - Targets

Q8NBK3

Orphanet

SUMF1

GlyGen

Q8NBK3

PDB

5SSX, 5SSY, 5SSZ, 2AII, 2HIB, 2AIJ, 2AIK, 8ARU, 2HI8, 1Y1E, 2AFT, 1Y1F, 1Y1H, 1Y1G, 1Z70, 2AFY, 1Y1J, 1Y1I

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51688 SGSH	5	SGSH R245H [lysosomal lumen] (R-HSA-2214347) SGSH C1091del [lysosomal lumen] (R-HSA-2214344) SGSH S66W [lysosomal lumen] (R-HSA-2214340) SGSH R74C [lysosomal lumen] (R-HSA-2214341) SGSH [lysosomal lumen] (R-HSA-1678689)	0.708	4
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.637	9
UniProt:Q99895 CTRC	1	pro-CTRC [zymogen granule] (R-HSA-9922787)	0.589	2
UniProt:P08842 STS	3	STS [endoplasmic reticulum lumen] (R-HSA-1614318) OxA-STS [endoplasmic reticulum lumen] (R-HSA-1614333) OxA-STS [endoplasmic reticulum membrane] (R-HSA-1606833)	0.527	2
UniProt:P22304 IDS	6	IDS (456-550) R468L [lysosomal lumen] (R-HSA-2210364) IDS (34-455) R443* [lysosomal lumen] (R-HSA-2210360) IDS (456-550) R468W [lysosomal lumen] (R-HSA-2210368) IDS (456-550) R468Q [lysosomal lumen] (R-HSA-2457604) IDS(34-455) [lysosomal lumen] (R-HSA-1678626) IDS(456-550) [lysosomal lumen] (R-HSA-1678681)	0.527	2
UniProt:Q9P246 STIM2			0.527	2
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.527	2
UniProt:Q96EG1 ARSG	2	ARSG [endoplasmic reticulum lumen] (R-HSA-1614361) OxA-ARSG [endoplasmic reticulum lumen] (R-HSA-1614304)	0.527	2
UniProt:P16233 PNLIP	2	PNLIP [extracellular region] (R-HSA-192419) PNLIP [zymogen granule] (R-HSA-9922845)	0.527	2
UniProt:P04066 FUCA1	3	FUCA1 [extracellular region] (R-HSA-6806209) FUCA1 [azurophil granule lumen] (R-HSA-6798773) FUCA1 [lysosomal lumen] (R-HSA-5693804)	0.527	2
UniProt:P34059 GALNS	6	GALNS G301C [lysosomal lumen] (R-HSA-2245324) GALNS R386C [lysosomal lumen] (R-HSA-2245326) GALNS I113F [lysosomal lumen] (R-HSA-2245331) OxA-GALNS [extracellular region] (R-HSA-6806214) OxA-GALNS [azurophil granule lumen] (R-HSA-6799224) OxA-GALNS [lysosomal lumen] (R-HSA-1630321)	0.527	3
UniProt:P15586 GNS	10	GNS [Golgi lumen] (R-HSA-434323) GNS [lysosomal lumen] (R-HSA-434208) GNS Q390* [lysosomal lumen] (R-HSA-2245231) GNS Q272* [lysosomal lumen] (R-HSA-2245247) GNS S94I [lysosomal lumen] (R-HSA-2245243) GNS R355* [lysosomal lumen] (R-HSA-2245238) GNS [ficolin-1-rich granule lumen] (R-HSA-6800961) GNS [extracellular region] (R-HSA-6806208) GNS [azurophil granule lumen] (R-HSA-6799222) OxA-GNS [lysosomal lumen] (R-HSA-1638063)	0.527	4
UniProt:P15289 ARSA	9	ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614334) ARSA(448-507) [endoplasmic reticulum lumen] (R-HSA-1614307) OxA-ARSA(19-444) [endoplasmic reticulum lumen] (R-HSA-1614359) OxA-ARSA(19-444) [lysosomal lumen] (R-HSA-508497) ARSA(448-507) [lysosomal lumen] (R-HSA-1606798) ARSA(448-507) [azurophil granule lumen] (R-HSA-6798775) ARSA(19-444) [azurophil granule lumen] (R-HSA-6798776) ARSA(448-507) [extracellular region] (R-HSA-6806249) ARSA(19-444) [extracellular region] (R-HSA-6806192)	0.527	3
UniProt:Q8NBK3 SUMF1	1	SUMF1 [endoplasmic reticulum lumen] (R-HSA-1614316)	0.524	3

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